PREGNANCY-BIRTH Messages for August, 2001: Re: PO magnesuim citrate-malate for PT labor?

Re: PO magnesuim citrate-malate for PT labor?

From: William McIntosh, MD (anonymous@obgyn.net)
Wed, 1 Aug 2001 09:35:55 -0500 (CDT)

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At Tue, 31 Jul 2001, erin wrote: >
>HI! I have been on modified bedrest for preterm labor symptoms for 4
>weeks. I am now 22 weeks. My cervix has changed to being anterior and
>soft, but is still long (6.1 cm at last US). My doc suggested starting
>nifedipine because of my amount of uterine acivity. It is my hope to
>avoid tocolytics, as long as I have no changes in my cervical length. As
>such, she suggested taking magnesuim citrate-malate cpsules 150mg
>(contains malic-acid 300mg) 4 times daily, with cutting back to 3 times
>if it gives me diarrhea. She said that this is an alternative to try
>over the standard tocolytics, and that it has worked to decrease uterine
>activity in some clients. I am on day 2 of this and the change is
>dramatic! I have only had 3 contractions today (that I can feel),
>compared to the countless numbers prior. I am having trouble finding
>any info about this supplement on the web. I just would like a second
>oppinion on the safety of taking this much PO mag, to baby and myself
>(one tab= 37.5% of DV). Have you ever seen this used? I am very happy
>with this treatment, as long as it is safe, as it appears to be working
>and no terb or nifetipine! Thank you for your reply!! Erin
>
>--
>Erin
>

PO Mag has been used for decades for tocolysis (IV Mag is the drug of choice for in-hospital tocolysis), but, alas, oral mag has never been shown to have any benefit in prolonging pregnancy, increasing birthweight, or any of the final outcome variables that we look at. Having said that, it is low risk in the fashion that you are using it, and if it makes you feel better, then OK.

-- William D. McIntosh, MD, FACOG

This is for educational purposes only, and is not a substitute for consultation and examination by a licensed medical professional.

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