PREGNANCY-BIRTH Messages for July, 2001: Re: Purinethol (6-MP) and affect on sperm

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Re: Purinethol (6-MP) and affect on sperm

From: rena (anonymous@obgyn.net)
Wed, 4 Jul 2001 03:12:16 -0500 (CDT)

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At Tue, 26 Jun 2001, Bob wrote: >
>My wife recently became pregnant and we know the exact conception date.
>Unfortunately, I began taking Purinethol (75mg/day) to treat
>Inflammatory Bowel Disease exactly two days before we conceived. Can
>anyone give any insight into whether this may have affected the sperm
>passed during conception. I know that it takes 70-85 days for sperm to
>be produced, so my hope is that the sperm is only affected by the drug
>during spermatogenesis and that the sperm involved in this conception
>were without risk or at least very little risk. Thanks for any and all
>information.
>
>-Bob

I have just found out that purinethol or, as we've known it 6-Mercaptopurine, is a potentially very dangerous drug to the fetus, my husband has been taking this for his Crohn's disease for several years (2+) and it has been working very well for him. We have had problems with infertility over the past year and it seems that both times I was actually pregnant (and had 2 miscarriages, within 4 months) chromosomal anomalies -such as a balanced translocation, and a trisomy- were found to be the cause of miscarriage. Well, I am also over-forty, relatively healthy and ovulating most of the time, and this is our first time trying to conceive; would anyone hazard a(n) (educated) guess about whether the 6-mercaptopurine could be a factor in our situation? My OB-GYN has a suspicion that it is, but my husband is somewhat reluctant (understandably so) to stop taking something so effective for him. I would certainly appreciate any input, or if there might be an article out there someone knows about that we could find about the 6MP...

Thanks, Rena

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Previous message: allison: "Anovulation? REVISED ? Q MISSED"

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