PREGNANCY-BIRTH Messages for April, 2001: Re: CMV Primary Infection?

Re: CMV Primary Infection?

From: M. Kelly Shanahan, MD, (anonymous@obgyn.net)
Sat, 21 Apr 2001 01:23:01 -0500 (CDT)

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In reply to: Ann: "CMV Primary Infection?"

At Fri, 20 Apr 2001, Ann wrote: >
>12 weeks into 4th pregnancy. 7 weeks I had blood drawn at commercial
>lab. CMV: IgM positive at 1.43 (Positive >1.10) and IgG 22.5 (Positive
>>0.7). Two weeks later blood drawn at a different commercial lab. IgM
>negative at 0.344. IgG positive at 189.2 (Positive >15.0). CDC says
>look for 4 fold rise in IgG titers with a rise in IgM to 30% of IgG --
>to diagnose an active, primary infection. My IgM became negative (not
>likely with an primary infection??) but with different labs the serum
>samples were not "paired" so not sure its possible to compare IgG
>numbers.

certainly the 2nd test suggests prior and not recent exposure, but you are right that it is impossible to compare as they were done in 2 different labs >
>Around children changing diapers for last 15 years, my 4 year old
>attends pre-school for last 2 years. 5 years ago, at 34, I had a VERY
>symptomatic case of mono (raised liver enzymes, fatigue, swollen lymph
>nodes, fever) -- blood tests revealed positive IgM to Epstein Barr,
>negative for EBV antibodies. NOT tested then for CMV.
>
>Isn't it more than likely that I HAVE already been exposed to CMV and
>that this is NOT a primary infection.

yes, given your long exposure to those little germ factories called children (I have had 2 bouts of tonsillitis and 1 cold in the last 3 weeks, thanks to mine!)

Does it make sense to go back to >Lab #2 for a third blood test?

yes

Perhaps first IgM was false positve. Or >am I better off going to a research lab (I am close to NYC).
>
>Doctor agressively pushing amnio. Am adamnantly opposed -- given my
>history and 2 days of bleeding at 10 weeks (since stopped) viewed on
>sonogram as minor misattachment of the placenta.
>
>I am aware that the statistics are in my favor even if this was a
>primary infection. But I sure would like a definitive answer one way or
>the other (without an amnio) and be able to finally rest easy. Thank
>you for any insight you may have.

have antoher test at lab #2

-- M. Kelly Shanahan, MD, FACOG South Lake Tahoe, CA

author, Your Over-35 Week-by-Week Pregnancy Guide available in all major bookstores and on-line at amazon.com http://www.amazon.com/exec/obidos/ASIN/0761526986/o/qid˜6597740/sr=8-1/ref=aps_sr_b_1_1/103-7407404-7691069http://www.amazon.com/exec/obidos/ASIN/0761526986/o/qid˜6597740

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Next message: M. Kelly Shanahan, MD, : "Re: Question!"
Previous message: M. Kelly Shanahan, MD, : "Re: cramping"
In reply to: Ann: "CMV Primary Infection?"

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