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CMV Primary Infection?From: Ann (anonymous@obgyn.net)Fri, 20 Apr 2001 21:50:02 -0500 (CDT)
12 weeks into 4th pregnancy. 7 weeks I had blood drawn at commercial lab. CMV: IgM positive at 1.43 (Positive >1.10) and IgG 22.5 (Positive >0.7). Two weeks later blood drawn at a different commercial lab. IgM negative at 0.344. IgG positive at 189.2 (Positive >15.0). CDC says look for 4 fold rise in IgG titers with a rise in IgM to 30% of IgG -- to diagnose an active, primary infection. My IgM became negative (not likely with an primary infection??) but with different labs the serum samples were not "paired" so not sure its possible to compare IgG numbers. Around children changing diapers for last 15 years, my 4 year old attends pre-school for last 2 years. 5 years ago, at 34, I had a VERY symptomatic case of mono (raised liver enzymes, fatigue, swollen lymph nodes, fever) -- blood tests revealed positive IgM to Epstein Barr, negative for EBV antibodies. NOT tested then for CMV. Isn't it more than likely that I HAVE already been exposed to CMV and that this is NOT a primary infection. Does it make sense to go back to Lab #2 for a third blood test? Perhaps first IgM was false positve. Or am I better off going to a research lab (I am close to NYC). Doctor agressively pushing amnio. Am adamnantly opposed -- given my history and 2 days of bleeding at 10 weeks (since stopped) viewed on sonogram as minor misattachment of the placenta. I am aware that the statistics are in my favor even if this was a primary infection. But I sure would like a definitive answer one way or the other (without an amnio) and be able to finally rest easy. Thank you for any insight you may have.
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