Re: Pregnancy and Indocin (Indomethacin).

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• In reply to: Shah: "Pregnancy and Indocin (Indomethacin)."

Here is the abstract of a review article on the use of Indomethacin. The reference is also available so that you can obtain a copy if you wish. Most libriaries should hav ethis service available.

Before you read it, let me say that I believe that a short course 3-4 days at this stage(14 weeks) in pregnancy is probably safe.

RDB

Prostaglandin synthetase inhibitors in pregnancy. Obstet Gynecol Surv 1993 Jul;48(7):493-502 (ISSN: 0029-7828) Van den Veyver IB; Moise KJ Jr Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030. The use of indomethacin as a tocolytic agent in patients with premature labor was first reported by Zuckerman in 1974. Since then, prostaglandin synthetase inhibitors (PSI) have been used in pregnancy for a variety of indications. However, serious fetal side effects of this category of drugs continue to be reported. We present a review of the literature and the experience at our institution on the use of indomethacin, the most commonly prescribed antiprostaglandin in pregnancy. Therapeutic guidelines and surveillance recommendations for the use of PSI in pregnancy are proposed. The role of newer PSI in pregnancy and their side effect profile are also presented. Major Subject Heading(s) Minor Subject Heading(s) CAS Registry / EC Numbers

Cyclooxygenase Inhibitors [therapeutic use] Pregnancy Complications [prevention & control] Cyclooxygenase Inhibitors [adverse effects] [contraindications] Fetal Diseases [chemically induced] [prevention & control] Forecasting Indomethacin [therapeutic use] Labor, Premature [prevention & control] Pregnancy Complications [chemically induced] Pregnancy 0 (Cyclooxygenase Inhibitors) 53-86-1 (Indomethacin)

Indexing Check Tags: Animal; Female; Human Language: English MEDLINE Indexing Date: 199311 Publication Type: JOURNAL ARTICLE; REVIEW (129 references); REVIEW, TUTORIAL Unique NLM Identifier: 93361296 Journal Code: M

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R.Daniel Braun, MD  FACOG   FOG

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• Next message: Holly: "Can you get too much Prometrium?"
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• In reply to: Shah: "Pregnancy and Indocin (Indomethacin)."