PREGNANCY-BIRTH Messages for December, 2000: Re: not aligned balanced translocation

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Re: not aligned balanced translocation

From: Lynn D. Montgomery, MD (anonymous@obgyn.net)
Wed, 20 Dec 2000 18:27:10 -0600 (CST)

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In reply to: Christine: "not aligned balanced translocation"

At Wed, 20 Dec 2000, Christine wrote: >
>My husband and I have miscarried twice in the past 6 months. We now
>have gotten genetic information back and they said that his chromosomes
>3 and 5 are translocated. One arm of three changed places with one arm
>of 5. They are calling this condition a "not aligned balanced
>translocation". Could anyone shed light on what exactly this means. We
>have an appointment with a genetic counselor but are really trying to
>get by until then. One doctor has told us we have about a 50% chance of
>miscarrying with each pregnancy. He did not mention any possibility of
>increased rates of physical or mental disabilities however several
>internet sites have talked about the increased posibilities of severe
>disabilities and malformations if it can even be carried to term and the
>chance that the child will carry the gene as well if he/she does
>survive. Any information you have would be greatly appreciated as we
>are just trying to handle this mentally one day at a time. As always
>thank you for helping us understand. Even when we don't like what we
>hear we are thankful to you doctors who can make things more clear.

You are going to be able to get a much better answer from the genetic counselor with the karyotype in hand. Normally these translocations are an "all or none" phenomenon-in other words either the fetus has it and is lost to miscarriage early or it doesn't have it and the pregnancy will be successful. Again, however, having the exact karyotype and having the genetic counselor look into it will provide much better insight into this particular translocation... Lynn

--
Lynn D. Montgomery, MD
Director, Maternal-Fetal Medicine
Rocky Mountain Perinatal Center
Missoula, Montana

**Note:  Opinions expressed here are for educational purposes only and, as such, do not constitute a physician-patient relationship.  This information is not intended to supplant the need for you to consult with your physician prior to choosing therapeutic options and/or interventions.

**Private e-mails cannot be entertained due to time constraints, consequently no private e-mails will receive a response.

**Thank you for your understanding ;-)

Next message: Lisa: "new drug docosanol and valtrex"
Previous message: Lynn D. Montgomery, MD: "Re: Chances of false positive on HPT?"
In reply to: Christine: "not aligned balanced translocation"

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