 |
 |
 |
|
|
|||
|
|
||||
|
||||
Re: Renova and PregnancyFrom: Rose (anonymous@obgyn.net)Sun, 7 May 2000 08:24:27 -0500 (CDT)
At Sat, 6 May 2000, nancy wrote: >Hi: >I was just reading through some archived information in this forum and noticed someone had a question about stretch marks. In reading through >it I discovered that Dr. McIntosh recommended using Retin-A AFTER pregnancy (obviously) to help reduce stretch marks. My problem is that I used it perhaps one time on my face (Renova, .05%)early in pregnancy prior to knowing that I was pregnant. (say 3rd or 4th week) It isn't something that I used alot of at any time, maybe once every 1 and half >to 2 weeks. The dosage indicated is less the size of a pea but after reading his remarks it has made me panic again because he had said it is know to have caused birth defects. I know that isotretinoins like Accutane have been most definitely linked to birth defects but have found very little indication of definitive links to Renova, Retin-A and >birth defects. My own ob-gyn expressed concern but felt the risk was minimal. Would any other medical personnel including Dr. McIntosh care to elaborate. My anxiety level is already pretty high as this is afirst time pregnancy for me. > >Thanks very much and keep up the great,informative advice. Nancy and Medical Personnel of Ob-gyn Net: Here is a great link re: this drug (Retin-A to be specific) http://www.rxmed.com/monographs2/cordema.html In it the monograph of this medication states: "Teratogenic effects. Pregnancy Category C. Oral tretinoin has been shown to be teratogenic in rats when given in doses 1000 times the topical human dose. Oral tretinoin has been shown to be fetotoxic in rats when given in doses 500 times the topical human dose. Topical tretinoin has not been shown to be teratogenic in rats and rabbits when given in doses of 100 and 320 times the topical human dose, respectively (assuming a 50 kg adult applies 250 mg of 0.1% cream topically). However, at these topical doses, delayed ossification of a number of bones occurred in both species. These changes may be considered variants of normal development and are usually corrected after weaning. There are no adequate and well-controlled studies in pregnant women. Tretinoin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus." As you can see oral tretinoin, not what you used, has more risk than topical which effectively showed no side effects. The doses that were given to lab animals were excessive and as you mentioned yourself, the amount that you used is insignificant if this monograph is true. Also at this site you can read what it says about systemic absorption: http://www.yorkpbm.com/cnu9805.htm "Systemic absorption is minimal and no teratogenic effects have been noted to date. Retin-A carries a pregnancy category rating of “B” while Renova (emollient cream) is rated category “C”. " Perhaps, I am not an MD or a pharmacist though, Renova is still considered class C because it is newer in its formulation and use but essentially the same medication from what I can determine based on chemical make-up. Thus information may be a bit more limited for it vs. the Retin-A. Also look at these sites: http://www.edoc.co.za/medilink/actives/1049.html http://becker.wustl.edu/lexicomp/patch_f/html/chapter/mono/hf126700.htm "Clinical effects on the fetus: Oral tretinoin is teratogenic and fetotoxic in rats at doses 1000 and 500 times the topical human dose, respectively; however, tretinoin does not appear to be teratogenic when used topically since it is rapidly metabolized by the skin." Once again these monographs support the fact that Renova in topical form does not appear to be teratogenic. Lastly, this site has a question from an MD to its forum: http://www.motherisk.org/update/mar98.htm Where once again it reiterates that topical tretinoin: "Available evidence suggests that topical tretinoin does not increase teratogenic risk in humans. " This information is dated from March 1998. It always gives an in-depth analysis of study methods which are supported from well respected journals such as New England Journal of Medicine, Lancet and Pediatrics. In the summarization of the study it states: "Our study includes the largest sample to date of women known to have used topical tretinoin during early pregnancy. Results failed to show increased risk of congenital malformations among these women. The two infants in the exposed group who were born with major malformations did not have the phenotype of retinoid embryopathy." All of the information that I have supplied to this forum appears to be from within the past three years. Perhaps others that have information would also like to elaborate. I hope this eases your mind.
|
| |
Women's Insurance Checklist from Auto Insurance Quote home | medical professionals | women | industry | forums | internationale-mail | about us | advertising | our sponsors | contact us | disclaimer | This information is provided for educational purposes only. Please read the disclaimer. ©1996-2008, all rights reserved. Do not reproduce without permission of MediSpecialty.com |
![[ Pregnancy & Birth Forum ]](/pregnancy-birth/pnb_forum_L.gif)