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Study begins of PCOS and pregnancyFrom: J.W.J. (anonymous@obgyn.net)Wed, 27 Nov 2002 10:45:19 -0600 (CST)
Someone sent this news to my e-mail and I thought I'd share it. Jessica STUDY BEGINS OF OVARY DISORDER Virginia Commonwealth University and Pennsylvania State Univeristy's Milton S. Hershey Medical Center have launched a study for women with polycystic ovary syndrome who want to become pregnant. Recruitment is under way at 13 medical centers across the country, said study leader Dr. Richard Legro, associate professor of obstetrics and gynecology at Penn State. The study could enroll as many as 678 women, ages 18 to 39, who suffer from the disorder of the endo- crine system. The condition causes hormone imbalances, leading to irregular menstrual cycles, excess facial and body hair, weight gain and adult acne. PCOS is a leading cause of female infertility, affecting up to 10 percent, or 5 million, women. "The goal is to test a combination of medications to bring about ovulation in women with in- fertility due to polycystic ovary syndrome," Legro said. "This investigation is important because few studies ever focus on pregnancy as an outcome due to the liability and ethical issues." Women with PCOS who meet the study cri- teria will be assigned at random to one of three medica- tion groups: comparing metformin XR (a sustained-release version of metformin) and placebo, an inactive pill; clomiphene citrate (the standard treatment for infertil- ity in women with PCOS) and placebo, and metformin XR and clomiphene citrate. Each arm of the study will contain at least one active medication that improves the chance for ovulation and, ultimately, pregnancy, Legro said.
-- J.W.J.
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