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Re: To whoever gives the 93% stat
From: Nif (anonymous@obgyn.net)
Sat, 28 Sep 2002 10:18:54 -0500 (CDT)
YAY, VICTORIA!!! I knew you'd have the goods!
--Jenn
At Sat, 28 Sep 2002, Victoria wrote:
>
>Hi,
>
>I'm going backwards through the posts. This might be the second study you are
>referring to?
>
>Metformin-induced resumption of normal menses in 39 of 43 (91%) previously
>amenorrheic women with the polycystic ovary syndrome.Glueck CJ, Wang P, Fontaine
>R, Tracy T, Sieve-Smith, L. Metabolism 1999;48: 511-519 (#4, April, 1999).
>On Metformin, 39 of 43 patients (91%) resumed normal menses.
>
>If so, Jenn is correct. Its always a good thing to read the studies themselves,
>sometimes its hard to see what is exactly going on or who was studied
>(overweight/obese women vs. thin women for example) without reading the study
>itself. I've made mistakes before in what I read and what I didn't. An old
>gotcha :) Btw, beware of percentages. In a study of 3 women, if 2 women are able
>to meet the study criteria for success, that's a 66% success rate. 3 women isn't
>a lot. 3000 is. Try to look at studies for the number of women in them, and what
>the criteria for selection are. It makes a big difference as to outcome.
>
>Was the first one: Nestler JE, Jakubowicz DJ, Evans WS, Pasquali R. Effects of
>metformin on spontaneous and clomiphene-induced ovulation in the polycystic
>ovary syndrome. NEJM 1998;338: 1876-80.
>
>The first might have been from either Glueck or Nestler. Maybe Perloe has it on
>his site. I'll try looking for the specific reference and post when I do. Have
>to run: going to an amusement park today and have church and long run tomorrow.
>
>--
>Victoria
>
>PS:
>
>1) Br J Clin Pharmacol 2002 May;53(5):469-73 Metformin does not enhance
>ovulation induction in clomiphene resistant polycystic ovary syndrome in
>clinical practice. Sturrock ND, Lannon B, Fay TN.
>
>CONCLUSIONS: Metformin is not always beneficial when given to clomiphene
>resistant infertile women with PCOS in clinical practice.
>
>2) Fertil Steril 2002 Apr;77(4):669-73 Pregnancies following use of metformin
>for ovulation induction in patients with polycystic ovary syndrome. Heard MJ,
>Pierce A, Carson SA, Buster JE.
>
>Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology
>and Infertility, Baylor College of Medicine, Houston, Texas, USA
>
>Result(s): Nineteen of 48 (40%) patients resumed spontaneous menses following
>treatment and showed presumptive evidence of ovulation with metformin alone;
>15/48 (31%) required CC (50 mg) in conjunction with metformin therapy, and 10 of
>these 15 (67%) had evidence of ovulation; 20/48 (42%) conceived with a median
>time to conception of 3 months, and 7 of these 20 (35%) had spontaneous
>abortions (SAB); 19/48 (40%) had gastrointestinal-related side effects, and 5 of
>48 patients (10%) had to decrease the dosage of metformin. Only 1 patient
>discontinued therapy.Conclusion(s): Metformin alone in patients with PCOS
>results in a substantial number of pregnancies, with 69% (20/29) of those who
>ovulated conceiving in less than 6 months.
>
>From: anonymous@obgyn.net (Nif)
>To: anonymous@obgyn.net
>Subject: Re: To whoever gives the 93% stat
>Message-ID: <anonymous@obgyn.net>
>
>I think when people make reference to the 90% # they are talking about
>the Metformin study of women trying to conceive but in that study the
>women were actually already pregnant and were testing to see if met
>lowers the miscarriage rate. Also in part of the study they make
>reference to "91%" of women regaining normal cycles while taking Met for
>6 months which then leaves people to think "oh, that must mean I can get
>pregnant" which it may. Unfortunately with percentages, there always
>has to be someone in the smaller percentage, I guess. Actually, Victoia
>really keeps up on the studies and articles so maybe she'll have a
>different answer when/if she responds to your post.
>--Jenn
>PS I can't imagine what you have gone through and I wish I had something
>consoling to say but I'm sure you've heard all of the well meaning
>people fall over their words before so I'll just say I'll be thinking of
>you. :)
>
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