PCOS Messages for September, 2002: Re: To whoever gives the 93% stat ALL SHOULD READ THIS! NOT JUST THOSE TTC

Re: To whoever gives the 93% stat ALL SHOULD READ THIS! NOT JUST THOSE TTC

From: Victoria (anonymous@obgyn.net)
Sat, 28 Sep 2002 09:46:00 -0400

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Hi a wonderful MD from the Jewish Hospital of Concinatti sent me a collection of data in a paper he cowrote to help encourage my infertility doc to put me on metformin. It has clinical data results from numerous studies and states the results in terms of met alone vs. met/clomid or met/IVF or met stopped at pregnancy vs met continued through pregnancy.

>> Did he say it had been corroborated by studies from other doctors?

He is careful to mention that there have been "38 open label and/or placebo controlled studies" to verify the use of metformin for restoring ovulation, insulin levels/ and conception.

>> You want double blind studies, not open label studies. There is chance
for bias to come into the study for that.

Another thing I have been stuggling to understand is why it appears ALL PCOS patients benefit from metformin and the answer is that not only do many have increased levels of insulin or insulin resistance - it is believed that the others might very well have an alteration in how there body uses (metabolizes) insulin. In other words our bodies (those with PCOS) has a difference in how it uses insulin to store/ convert simple dietary nutrients into what we need to fuel our bodies. It is likely that close family relatives (male and female) possess this same dysfunction which can one day lead to all the bad effects (heart disease, high blood pressure, diabetes, high cholesterol) that altered insulin metabolism can cause.

>> One study came out with 50% of relatives (believe mother/sister combos)
having PCOS like symptoms/problems. I may have that on my PCOS articles page. I have a bunch that haven't been added due to researching another area.

I know this has been long winded but Dr. Glueck supplied me with medical knowledge I need - and I hope it useful to all of you. He also offered me to come to Cincinatti for initial work-up and long distance treatment coordinated with a primary OB/GYN or medical doctor. So if any of you can travel it could be ideal if you keep hitting the brick wall!

>> I'd check the cost out first and whether or not it would be covered under
insurance.

>> Victoria

Denise/ NC

--
Red Roo

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