PCOS Messages for July, 2002: Re: Glucophage Dosing WAS: Agitated

Re: Glucophage Dosing WAS: Agitated

From: Sonnet (anonymous@obgyn.net)
Fri, 5 Jul 2002 12:01:16 -0500 (CDT)

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In reply to: tera: "Re: Agitated (somewhat long)"

Just jumping in and adding two cents - per usual!!

(OK totally OT, when did they take the "cents" sign off of keyboards? What did they add in its place? I know it was a while ago, but they all had them when I was a kid...)

ANYWAY, yes, as tera said I'm on a really high dose. I currently take 3g of glucophage - not generic met, which made me very very sick - a day. I get my liver checked every few months just in case. So far, so good! My endo claims that just because a drug company has a highest recommended dose doesn't mean you can't go over it if your doctor thinks it's safe and useful for you. He also used the "This would be a perfectly normal dose in Europe" argument. I don't know that that's true, but I did need a higher dose so I didn't argue too much.

BMS, the company that makes Glucophage, recommends that you start off taking it VERY slowly, and work up until you either a) hit a dose that works to control your symtpoms, or b) reach 2550mg/day. So no specific prescribed amount.

I will say that in almost all of the medical studies I've seen on using Glucophage to treat PCOS, the dose they used for the studies was 1500mg. This SEEMS to be a pretty standard dose, but your body might need more or less. I have been told by a couple of endos that standard dosing for diabetics is 1000mg and for PCOS is 1500mg. Again, that's just a general guideline.

If you're going up to 2550mg, remember to do so very very slowly, like 1/2 or 1/4 of a pill at a time, especially if they're 850mg pills. Do it over several weeks so your body can adjust. And, if you find that your PCOS symptoms seem to start being well controlled at, say, 1500mg or so, you can always stop there.

At Fri, 5 Jul 2002, tera wrote: >
>Hi Christie!
>
>That does seem like a big jump in Met to me too. There is not really a
>"set" dose for PCOS. Some doctors say that there IS a dose that is
>supposed to be therapeutic (I think the "therapeutic" dose is about 1500
>mgs) but that "one size fits most" approach is not always a good one
>with PCOS. I've been on 500 mgs per day and that low dose is all I need
>to get regular again and that low dose is "therapeutic" for me. I got
>REALLY ill on upwards of 1800 mgs. If you're going to go that high,
>have your liver checked regularly. There are women who post on this
>site that have had to go that high - correct me if I'm wrong but I think
>that Sonnet is on a pretty high dose.
>

You may want to slowly up your dose as your doctor suggested until >you start seeing results. You probably don't want to take a dose that
>is higher than you need, right? I have heard from my doctors that
>prescribing Met for PCOS women is like taking a shot in the dark - they
>don't know how high to go.
>
>>At Tue, 2 Jul 2002, Christie wrote:
>>>

the doctor upped my >>>dosage of Met to 850mg 3x a day. Isn't that a big jump? He gave me a
>>>table to follow to gradually take me from 1000mg to 850mg x3, but it
>>>just seemed like a lot

--
email always welcome: sonnet_fitz@hotmail.com

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