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Re: Use of Metformin for women w/o IR
From: tera (anonymous@obgyn.net)
Fri, 5 Jul 2002 09:16:29 -0500 (CDT)
Hi!
This is really good info. Thank you. God bless, Tera
At Tue, 2 Jul 2002, Pat wrote:
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>Title: ENDO: Insulin-sensitizing Medications Aid Polycystic Ovary
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>Syndrome, Even Without Insulin Resistance, Obesity
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>"ENDO: Insulin-sensitizing Medications Aid Polycystic Ovary Syndrome,
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>Even Without Insulin Resistance, Obesity"
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>By Paula Moyer Special to DG News SAN FRANCISCO, CA -- June 20, 2002 --
>Treatment with insulin-sensitizing medications such as metformin
>(Glucophage®) promotes ovulation and reduces testosterone levels in
>women with polycystic ovary syndrome (PCOS), even if they are relatively
>lean and insulin-responsive. These findings, reported at ENDO 2002, the
>84th Annual Meeting of the Endocrine Society, indicate that physicians
>may want to use insulin-sensitizing therapy in all women with PCOS,
>rather than relying on clinical assessments of insulin sensitivity,
>according to the investigators. "Even if a woman with PCOS doesn't have
>obesity or other symptoms that would lead the physician to suspect
>insulin resistance, insulin-sensitizing drugs are effective," lead
>investigator Jean-Patrice Baillargeon, MD, said. "It was a surprising
>outcome to see that relatively lean women will have lower insulin
>levels, begin to ovulate, and have lower testosterone levels." Dr.
>Baillargeon is a clinical research fellow in endocrinology at Virginia
>Commonwealth University in Richmond, Virginia, United States and
>collaborated in his research with John Nestler, professor of medicine at
>Virginia Commonwealth University. Dr. Baillargeon is currently on
>leave from his position as a professor of medicine at the University of
>Sherbrooke in Sherbrooke, Quebec, Canada. In this study sponsored by
>the National Institutes of Health, Dr. Baillargeon and colleagues
>randomly assigned 100 women with PCOS who were neither overweight nor
>hypertensive to receive metformin, rosiglitazone (Avandia®), combination
>therapy, or placebo. The doses for the insulin sensitizers were 850 mg
>twice daily for metformin and 4 mg twice daily for rosiglitazone. Every
>six months, the investigations assessed the women with respect to number
>of ovulations during the observation period, any changes in systolic
>blood pressure, and changes in free testosterone. The average body mass
>index (BMI) for the women was 24.5, which is considered to be within
>normal weight. The metformin monotherapy group had a mean of 3.3
>ovulations during this period, compared to 2.4 for the rosiglitazone
>monotherapy group and 3.4 for the combination group. The placebo arm
>had a mean of 0.4 ovulations during the study period (p<0.0001). The
>metformin group had a mean reduction of 4.3 mm Hg in systolic blood
>pressure, compared to 2.6 mm Hg for the rosiglitazone group, 4.5 mm Hg
>for the combination group, and 1.0 mm Hg for the placebo group
>(p=0.012). Free testosterone levels dropped 12.8 pmol/L in the
>metformin group, 12.3 pmol/L in the rosiglitazone group, 21.9 pmol/L in
>the combination group, and 1.2 pmol/L in the placebo group (p=0.0001).
>"If using an insulin sensitizer, rosiglitazone alone will not produce
>sufficient change in PCOS symptoms," Dr. Baillergeon said. "Either
>metformin monotherapy or combination therapy should be used."
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--
Tera
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