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Re: Link between Type II diabetes and pcosFrom: paula (anonymous@obgyn.net)Wed, 5 Jun 2002 14:36:53 -0500 (CDT)
oops pat, i forgot that i was supposed to send you my list of links..please forgive me =) here are a few that helped me determine that i do indeed believe that insulin resistance is the underlying cause of PCOS. i personally believe that the insulin tests available now are not necessarily sensitive enough to pick up every case of insulin resistance. it is my contention that every PCOS patient has insulin issues to varying degrees. http://www.mja.com.au/public/issues/nov16/kidson/kidson.html in this article it says "Insulin resistance leads to hyperinsulinaemia as pancreatic insulin secretion rises to maintain normoglycaemia. Hyperinsulinaemia can then stimulate lipid storage, altered lipoprotein and cholesterol metabolism and (possibly) altered steroid hormone metabolism. Hyperinsulinaemia increases ovarian androgen production 19 by stimulating an ovarian enzyme complex cytochrome P450c17, either directly and/or by stimulating pituitary luteinising hormone secretion." http://blues.fd1.uc.edu/~gartsips/polycyst.htm#PCOS This page which contains studies my Dr. Glueck, says "The central, probably heritable, biochemical abnormality of polycystic ovary syndrome (PCOS) is hyperinsulinemia. This leads to ovarian overproduction of testosterone and to adrenal overproduction of DHEAS and androstenedione.These changes, particularly the increased testosterone, in turn affects the pituitary-ovarian axis, leading to abnormal production of LH and FSH (which stimulate the ovaries). The result of LH and FSH abnormalities is ovarian underproduction of estrogen, along with abnormal production of progesterone, overproduction of testosterone, and amenorrhea and infertility." http://www.ivf.com/pcostreat.html this article by Mark Perloe, M.D says "There is increasing data that hyperinsulinemia produces the hyperandrogenism of polycystic ovary syndrome by increasing ovarian androgen production, particularly testosterone and androstenedione and by decreasing the serum sex hormone binding globulin concentration. The high levels of androgenic hormones interfere with the pituitary ovarian axis, leading to increased LH levels, anovulation, amenorrhea, and infertility. Hyperinsulinemia has also been associated high blood pressure and increased clot formation and appears to be a major risk factor for the development of heart disease, stroke and type II diabetes." http://content.nejm.org/cgi/content/short/340/17/1314 This study, done by John E. Nestler, M.D., Daniela J. Jakubowicz, M.D., Paula Reamer, M.A., Ronald D. Gunn, M.S., and Geoffrey Allan, Ph.D., came to this conclusion "d-Chiro-inositol increases the action of insulin in patients with the polycystic ovary syndrome, thereby improving ovulatory function and decreasing serum androgen concentrations, blood pressure, and plasma triglyceride concentrations." indicating that the improvement of insulin function can help to restore the effectiveness of other endocrine glands. hope this helps explain my position. love, paula
-- please feel free to email me at paulam@communicomm.com
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