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Re: Another question on Insulin Resistance

From: Belle (anonymous@obgyn.net)
Mon, 3 Jun 2002 16:46:10 -0500 (CDT)


You can be very thin and still have IR (insulin resistance). You can be very young and have insulin resistance. My very thin 15 year old tested insulin resistant at age 13 and about 115 pounds. She still needs to watch her carb intake (since she is still a teen, she does a modified carb reduction). She is also on Glucophage. It has totally regulated her periods. You should monitor your carbs because since you have PCOS, it is very likely that you are putting undue stress on your body. You can do this by cutting back on white bread, white potatoes, white rice and pasta. You can make small changes that will not hurt but will be of great benefit to you.

While we could all tell you when we began to gain weight, it may not be benficial to you since PCOS is different for everyone. My first symptom was hairloss, I did not gain weight until about 2 years after my children were born. My mother (many of the same genes obviously) had her first symptom as two week long periods. My daughter (still same genetic pool) had her first symptom as missing periods! Half of the women with PCOS are thin. Some women with PCOS were heavy as children. PCOS is so hard to predict. The best thing for us is to become as informed as we possibly can and work from there to maintain the best health that we can.

Insulin resistance can make a fasting glucose show up as low when tested. This is because our cells do not readily accept the insulin that we produce. Insulin is necessary in getting glucose into the cells, it is the "key" to the cell "door". Glucose attaches to insulin and the insulin gets the glucose into the cell to be used as fuel. If your cells do not accept the insulin immediately, your body senses that you still have too much glucose in your bloodstream and releases more insulin. You eventually get enough insulin in your system to "bully" its way into the cell. All of this excess insulin will clear your blood stream of even more glucose - resulting in a lower glucose level. If you glucose level is high, you may already have crossed the line into diabetes.

If you have PCOS and your doctor is familiar with the mountain of research that has come out in the last few years, you will have your insulin tested or you will be put on Glucophage (metformin) as a treatment without the test. The reason for this is because the original research on women with PCOS and Glucophage did not require women to be insulin resistant.

The test for insulin resistance is very expensive and only done in research settings. The test that we use instead is a glucose tolereance test with insulin levels taken at the same time (IGTT). This is a test where you enter in a fasting state (not food, drink, smoking or exercise for 8 hours before the test or since midnight the night before) with fasting levels of glucose and insulin taken (two tubes - red top and grey top). You then drink a sugar soda (like cola or orange soda) and wait for a while. Blood test are then taken at 30 minutes (sometimes), one hour and two hours. The test can be 2, 3, or 5 hours long but the two hour test is sufficient for us. The 5 hour test tends to put too much stress on the body for a lot of people. The fasting levels alone are not very informative for most people because we need to see the body reacts to the stress of glucose (food). We then need to look at the ratio between the two numbers (from insulin and from glucose levels).

At Wed, 22 May 2002, Jess wrote: >
>I am almost 25. My weight fluctuates like 10-15 pounds , but i really
>don't have a problem loosing it when i want to. What is your sugar and
>carb intake like on a daily basis. What is the max that you allow
>yourself? I am not sure what is a lot and what is ok. I just eat
>whatever I want most of the time, but I do limit my caleries to about
>1500-1800 every day.
>
>At what age did you start gaining weight?
>
>why would glucose level be low when you have insulin resistance. do you
>know? would my dr just give me an insulin resistence test if i ask? i
>thought they would only do it if your glucose levels are high.
>
>>At Wed, 22 May 2002, ellen wrote:
>>>
>>>I have all the other symptoms of pcos, but do I have insulin resistence
>>>if I am really thin and have no trouble loosing weight? Do pcoser's
>>>watch their sugar and carb intake in order to maintain their weight or
>>>in order to control their pcos symptoms? I am really bad with the sugar
>>>and carb thing b/c I can't stop eating them. If I am not concerned with
>>>the weight thing, could I eat whatever I want? Would that effect my pcos
>>>symptoms like hair growth and acne? please help. I am so confused...
>>
>>Yes, you can be slightly borderline IR even if you are thin at this
>>time. I assume you are quite young right now? How old are you? Later
>>on, you MIGHT start having trouble. PCOSers watch their carb/sugar
>>intake to help control IR which helps control weight and all other PCOS
>>symtpoms. If you are having trouble adjusting your diet on your own,
>>maybe you can go see a nutritionist for some advice and tips, one who is
>>aware of IR problems. I never had acne because of my overly healthy
>>eating and skincare habits, but my hair problems got worse as I got
>>older even with all my good habits. It's almost like eventually IR is
>>determined to win no matter what you do.
>>
>>>ps: I never got an insulin resistance test, but my glucose level is
>>>really low after fasting for about 24 hours, so I guess doctors are not
>>>concerned about the diabetes and insulin resistance problem. Are they
>>>correct in making that assumption?
>>
>>IR shows up on a fasting blood test that tests both glucose AND
>>insulin...usually the glucose is a bit low (as it is in your case) and
>>the insulin is a bit high (over 10) at the same time.

--
Hope this helps,

Belle




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