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Re: Type II diabetes, be hyperinsulemic, but not have pcos?
From: Jan (anonymous@obgyn.net)
Thu, 30 May 2002 11:47:54 -0500 (CDT)
I guess my next question is if insulin resistance means that your cells
don't utilize insulin and so the insulin levels build up, contributing
to high levels of androgens.........what about women who have insulin
resistance and have type 2 diabetes but don't have pcos? How come when
their insulin levels build up, it don't cause high levels of androgens
for them? There are so many women out there with type 2 diabetes and
insulin resistence too...
At Wed, 29 May 2002, Pat wrote:
>
>You can be Type II diabetic and have high insulin levles, because you
>are inslulin resistant. Or you can be almost diabetic, with borderline
>levlels, suggesting impaired glucose tolerance. Insulin resistance
>means your cells don't utilize insulin, and the insulin levles build up.
>According to some authors, high levels of inslulin contribute to high
>levels of androgens, which is characteristic of PCOS. It is sort of a
>continum, one step at a time. So, the object is to slow this
>progression. I suspect one could have any combination of things, and
>might or might not have PCOS. Here is an article, with associated web
>site:
>
>HYPERINSULIN & PCOS? [http://www.ivf.com/pcostreat.html]
>As of yet, we do not understand why one woman who demonstrates
>polycystic appearing ovaries on ultrasound has regular menstrual cycles
>and no signs of excess androgens while another develops PCOS. One of
>the major biochemical features of polycystic ovary syndrome is insulin
>resistance accompanied by compensatory hyperinsulinemia (elevated
>fasting blood insulin levels). There is increasing data that
>hyperinsulinemia produces the hyperandrogenism of polycystic ovary
>syndrome by increasing ovarian androgen production, particularly
>testosterone and androstenedione and by decreasing the serum sex hormone
>binding globulin concentration. The high levels of androgenic hormones
>interfere with the pituitary ovarian axis, leading to increased LH
>levels, anovulation, amenorrhea, and infertility. Hyperinsulinemia has
>also been associated high blood pressure and increased clot formation
>and appears to be a major risk factor for the development of heart
>disease, stroke and type II diabetes.
>
>Pat
><<someone clarify if you can have Type II diabetes, be hyperinsulemic,
>>but not have pcos?>>>
>>
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