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Re: Rezulin and PCOS

From: Victoria (anonymous@obgyn.net)
Thu, 14 Mar 2002 22:20:25 -0500


So was thalidomide. However, thalidomide is showing some promise as a treatment for multiple myeloma.

--
Victoria

> From: anonymous@medispecialty.com (Belle)

> While the testing with Rezulin looked very good, it has been taken off > of the market here because of the health problems that it created. > > At Wed, 13 Mar 2002, Victoria wrote: > > > > Troglitazone, an Insulin-Sensitizing Thiazolidinedione, Represses Combined > >Stimulation by LH and Insulin of de Novo Androgen Biosynthesis by Thecal Cells > >in Vitro -- Journal of Clinical Endocrinology and Metabolism > > > ><a href=http://www.obgynlinx.com/thearts.cfm?artid=314104&specid=5> > >http://www.obgynlinx.com/thearts.cfm?artid=314104&specid=5 </a> > > > >This ensemble of inhibitory actions on LH/insulin-stimulated steroidogenesis > >offers a plausible mechanistic basis for at least part of the observed clinical > >efficacy of troglitazone in mitigating androgen excess in women with polycystic > >ovarian syndrome...

> >Victoria

> Belle




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