PCOS Messages for February, 2002: Re: What could this mean--high cortisol levels!

Re: What could this mean--high cortisol levels!

From: cat (anonymous@obgyn.net)
Mon, 25 Feb 2002 00:10:46 -0600 (CST)

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Hi, I was reading the archives and came across this old message. I wondered if I had cushings because I have accumulaiton of fat all on my belly and also on my back and shoulders (buffalo hump), with fairly normal size arms, legs etc. I have been trying to find out if high testosterone alone causes this, but everything I've read says it is high cortisol.

How does insulin resistance cause high cortisol? Is it because it is a form of stress? And are there any drugs or other ways to reduce cortisol? If you correct the insulin resistance by taking metformin does the cortisol reduce?

Thanks for any help,

--
Cat xxx

At Mon, 26 Nov 2001, anonymous wrote:
>
>High cortisol levels could indicate Cushings.  But high cortisol levels
>are seen in people in general with insulin resistance.  I do rearch on
>patients with HIV lipodystrophy which involves insulin resistance and
>some of these patients have high cortisol levels and buffalo humps but
>they do not have Cushings.  As far as PCOS and "normal" blood work, yes
>it is possible for everything to be in the limits of normal and still
>have PCOS.  Usually it is diagnosed by 1) irregular or absent periods;
>2) hyperandrogenism: acne and/or male pattern body hair; and 3)
>exclusion of other endocrine disorders.
>
>At Mon, 26 Nov 2001, Rhonda wrote:
>>
>>Hi! I have posted here in the past couple of months.  I have been to an
>>endocrinologist.  I have done lots of blood work.  The testosterone and
>>c-peptide (sp?) were all normal.  The cortisol level from a 24 hour
>>urine collection was high and I need to recheck it.  I have all the
>>symptoms of pcos.  Could you still have it and the bloodwork be normal?
>>I have been reading about cushings today.  Does anyone know about this
>>and can tell me more? Thanks in advance, Rhonda

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