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Metformin and Clomid From: Sonnet (anonymous@obgyn.net) Mon, 18 Feb 2002 16:45:25 -0600 (CST) Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: lynsey: "Re: Very depressed, Please help...need advice." Previous message: Beth: "Re: Visited with my endocrinologist" Last night at the chat quite a few people asked about an article I sometimes refer to that shows the efficacy of metformin + clomid therapy to treat infertility in PCOS. I sent them this email today and thought maybe someone here might benefit from the info as well: You guys had asked about a study I have info on showing the efficacy of usin metformin and clomid together. It might really help convince a doctor if need be! The article is by Drs J Nestler, D Jakubowicz, W Evans et al. It is titled "Effects of Metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovarian syndrome." It was published in the New England Journal of Medicine, 1998; 338: 1876-1880pp. There is an abstract here: http://content.nejm.org/cgi/content/abstract/338/26/1876?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=jakubowicz&searchid=1014071757402_26352&stored_seowicz&searchid=1014071757402_26352&stored_search=&FIRSTINDEX=0&sortspec=PUBDATE_SORTDATE+desc+Score+desc&journalcode=nejm but you have to be registered of something with the NEJM to read the whole thing. A comment I have in a different PCOS article (http://www.mja.com.au/public/issues/nov16/kidson/kidson.html) says about their results: "A recent controlled trial was performed in the United States, Venezuela and Italy in which obese women with polycystic ovary syndrome were given either metformin or placebo.30 Women in both groups who had not ovulated by Day 35 were given clomiphene as additional medication. By Day 35, 34% of women taking metformin had ovulated, compared with only 4% of the placebo-treated women (P < 0.001). Within 18 days after the addition of clomiphene, 90% of the remaining women taking metformin ovulated, compared with 8% of the placebo-treated women (P < 0.001). In summary, within 53 days only 7% of women treated with metformin or metformin plus clomiphene had not ovulated, compared with 88% of women treated with clomiphene alone." (the "30" footnote it has refers to the article in the NEJM.) This is a *very* striking result in treating PCOS infertility - 88% of PCOS women treated with Clomid alone did not ovulate. 93% of PCOS women given both clomid and metformin DID, within 53 days! Pretty impressive! -- Email always welcome: sonnet@pcosupport.org Next message: lynsey: "Re: Very depressed, Please help...need advice." Previous message: Beth: "Re: Visited with my endocrinologist"

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