PCOS Messages for February, 2002: Re: WebMD - Insulin Pill Fights Obesity

Re: WebMD - Insulin Pill Fights Obesity

From: Belle (anonymous@obgyn.net)
Wed, 6 Feb 2002 00:19:27 -0600 (CST)

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In reply to: Alicia: "Re: WebMD - Insulin Pill Fights Obesity"

It makes sense because our bodies do not just let the glucose sit around in our systems. When we have some food, the carbs are sugars that would normally be used as fuel. Since we have a problem with our cells, the insulin does not enter the cell correctly so our pancreas pumps out more. Eventually we get enough insulin in our systems to "bully" its way into the cell.

Remember, our bodies have a difficult time accepting the insulin but eventually it does work. If our cells never let the insulin, our GTT would show some startling results! Our blood sugar would never go back down and we would have had all of the problems that Type I diabetics suffer from. Amputations would be the least of our worries.

Think about your GTT, the insulin levels should have gone up in the first hour and you should have seen some reduction in the glucose levels by the second hour. This proves our insulin does eventually get into the cell, unfortunately, by the time it does, we have over-produced the insulin.

If we were able to take an insulin pill, we would have the adequate amount of insulin in our systems to take care of the glucose from the *beginning* and we would not take the risk that our pancreas would *over produce* the insulin.

The only analagy that I can come up with is the same one I use for the birth control pill so some of you may have heard this before. Imagine you are pushing a wheel barrow up a hill, you know the amount of pressure that you need to push it. Suddenly, the front tire hits a rock. You push harder. When you finally get the wheel barrow over the rock, you end up pushing the wheel barrow a lot further than the place where the rock was because you were applying so much pressure to get over the obsticle. You overshoot. The same is true with the insulin, you over produce. If you had known the rock was coming up and you would have been able to do something to avoid it. Well, if you are going to eat, you know that a load of glucose (or carbs) is coming so to avoid the overproduction of insulin, you go ahead and plan for it.

Whether it is understood or not, it obviously works in mice in this study. There will not be a human form of this insulin for a number of years since the research will have to be repeated in order to be deemed valid, then further trials will have to be performed with human subjects. Perhaps by that time, we will have found a cure for PCOS or another form of treatment for IR. We can always hope.

At Tue, 5 Feb 2002, Alicia wrote: >

Did you read my response???? Well I appreciate you explaining it, It does not make >sense to me.
>
>Alicia
>
>At Mon, 4 Feb 2002, Panacea wrote:
>>
>>At Mon, 4 Feb 2002, Belle wrote:
>>>
>>>Let me try again, I think that I am a little more cognizant than I was
>>>at 2 this morning. The bottom line is that we have too much insulin and
>>>get sugar lows because we over-compensate. We eat something then our
>>>body struggles to deal with the sugar and we pump out more and more
>>>insulin. If we do not have adequate assistance (such as an insulin
>>>sensitizing drug), we will get *too much* insulin in reaction to the
>>>glucose.
>>>
>>>It is thought that if you have the insulin ready, the glucose will be
>>>metabolized before your pancreas has an opportunity to deliver the
>>>excess insulin. When this is the case, you end up with **less insulin
>>>in your system**.
>>
>>That doesn't make sense. Our body pumps out more insulin because the
>>insulin doesn't work. IE our body doesn't know what to DO with it.. it
>>wouldn't matter if the insulin was ours or someone else's.
>>
>>--
>>Panacea
>>
>--
>Alicia
>

-- Hope this clears things up,

Belle

Next message: Belle: "Re: had some blood work done"
Previous message: Jessica: "Question about a conflict between blood levels and symptoms"
In reply to: Alicia: "Re: WebMD - Insulin Pill Fights Obesity"

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