Re: WebMD - Insulin Pill Fights Obesity
From: Belle (anonymous@obgyn.net)
Mon, 4 Feb 2002 20:16:35 -0600 (CST)
Let me try again, I think that I am a little more cognizant than I was
at 2 this morning. The bottom line is that we have too much insulin and
get sugar lows because we over-compensate. We eat something then our
body struggles to deal with the sugar and we pump out more and more
insulin. If we do not have adequate assistance (such as an insulin
sensitizing drug), we will get *too much* insulin in reaction to the
glucose.
It is thought that if you have the insulin ready, the glucose will be
metabolized before your pancreas has an opportunity to deliver the
excess insulin. When this is the case, you end up with **less insulin
in your system**.
While I am not involved with this research and I know nothing about it
except what I read on WebMD, I have heard of this theory before and it
makes sense at a cellular level. The up side would be that 1) research
is being done to help us with IR (Yea!!!) and 2) if our pancreas does
not have to work as heard, it may not give out as quickly.
Is this better?
At Sun, 03 Feb 2002, Renee wrote:
>
>Sorry; I'm still confused.
>
>We do make to much insulin. You explained the process where it then drains
>the sugar from our bloodstream, creating hunger and creating fat. I
>understand that. What I don't understand is why adding more insulin would
>help the problem. It would seem to me that it would make it worse, draining
>the blood stream faster. I'm working hard to keep my insulin levels down with
>super-low-carbing and met. Why in the world would I want to add more insulin
>to my bloodstream when I'm trying to keep it minimized?
>
>Renee
>
>Belle wrote:
>> There is a theory that if people who are IR get enough insulin from the
>> beginning, the pancreas would not have to work so hard to pump enough
>> out. We have a "trigger" that tells us when we are full. People who
>> are IR never reach that point where the trigger goes off telling us to
>> stop eating. Added insulin would help with that. The insulin in our
>> system would take care of all of the "fuel" without the time delay of
>> the pancreas. We have seen from our IGTTs (Insulin and Glucose
>> Tolerance Test) that it may take 2 or 3 (or more) hours before our
>> glucose returns to a normal reading. This would not happen if we had
>> the insulin ready for use to overcome the cell. Less food, less sugar
>> that can be converted to fat.
>>
>> More importantly for us is that we do not end up putting out TOO much
>> insulin. You know those days (before low carbing) when you would eat
>> breakfast and get a sugar high, then you would be hungry in two hours?
>> This is because you body has put out insulin in response to the glucose
>> in you system and TOO much glucose was taken out of the bloodstream,
>> creating a hunger. If we had the insulin already there, we could more
>> easily regulate our bloodsugar levels. Again, less food that can be
>> converted to fat.
>>
>> This is the same principle that *may* cause people to loose weight on
>> Glucophage. If you are able to use the "fuel" that you give your body,
>> and use it efficiently, you would not need as much.
>>
>> I want to be perfectly clear that I am not saying that all women who are
>> IR overeat. I know that I watched my intake very carefully and went
>> around feeling hungry much of the time and still I gained weight. I
>> also know that I had low bloodsugar to go along with my weight. Iam
>> sure all of that *extra* glucose that was taken out of my system by my
>> insulin was used for fat!!! :-)
>>
>> Does this make sense? It is very late here and I am not sure I am using
>> complete sentences. :-)
>>
>> At Sun, 03 Feb 2002, Renee wrote:
>> >
>> >I read the article. It doesn't make a lot of sense to me. They gave an
>> >insulin-like substance (first they did insulin) to IR overweight rats. They
>> >found the rats ate less and lost weight.
>> >
>> >This seems contrary to what my understanding is. With IR, you have too much
>> >insulin floating around. The extra insulin converts blood sugar to fat, as
>> >well as the other hormonal effects we experience. Why would giving insulin or
>> >an insulin-like substance to someone with too much insulin help?
>> >
>> >Does this make sense to anyone else?
>> >
>> >Renee
>>
>> --
>> Hope this helps,
>>
>> Belle
>>
>--
>Renee Cordrey, MSPT, MPH, CWS
>
>---
>
>Don't follow in the footsteps of the masters. Seek what they sought.
> --Zen saying
>
--
Hope this helps,
Belle
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