PCOS Messages for February, 2002: Re: WebMD - Insulin Pill Fights Obesity

Re: WebMD - Insulin Pill Fights Obesity

From: Belle (anonymous@obgyn.net)
Mon, 4 Feb 2002 01:18:00 -0600 (CST)

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Reply: Alicia: "Re: WebMD - Insulin Pill Fights Obesity"

They gave the insulin initally to see if it would be beneficial, they developed the pill because that is the only way it would be used by the masses. No one likes shots. I know I hate mine (not insulin but an inter-muscular injection for another malady).

There is a theory that if people who are IR get enough insulin from the beginning, the pancreas would not have to work so hard to pump enough out. We have a "trigger" that tells us when we are full. People who are IR never reach that point where the trigger goes off telling us to stop eating. Added insulin would help with that. The insulin in our system would take care of all of the "fuel" without the time delay of the pancreas. We have seen from our IGTTs (Insulin and Glucose Tolerance Test) that it may take 2 or 3 (or more) hours before our glucose returns to a normal reading. This would not happen if we had the insulin ready for use to overcome the cell. Less food, less sugar that can be converted to fat.

More importantly for us is that we do not end up putting out TOO much insulin. You know those days (before low carbing) when you would eat breakfast and get a sugar high, then you would be hungry in two hours? This is because you body has put out insulin in response to the glucose in you system and TOO much glucose was taken out of the bloodstream, creating a hunger. If we had the insulin already there, we could more easily regulate our bloodsugar levels. Again, less food that can be converted to fat.

This is the same principle that *may* cause people to loose weight on Glucophage. If you are able to use the "fuel" that you give your body, and use it efficiently, you would not need as much.

I want to be perfectly clear that I am not saying that all women who are IR overeat. I know that I watched my intake very carefully and went around feeling hungry much of the time and still I gained weight. I also know that I had low bloodsugar to go along with my weight. Iam sure all of that *extra* glucose that was taken out of my system by my insulin was used for fat!!! :-)

Does this make sense? It is very late here and I am not sure I am using complete sentences. :-)

At Sun, 03 Feb 2002, Renee wrote: >
>I read the article. It doesn't make a lot of sense to me. They gave an
>insulin-like substance (first they did insulin) to IR overweight rats. They
>found the rats ate less and lost weight.
>
>This seems contrary to what my understanding is. With IR, you have too much
>insulin floating around. The extra insulin converts blood sugar to fat, as
>well as the other hormonal effects we experience. Why would giving insulin or
>an insulin-like substance to someone with too much insulin help?
>
>Does this make sense to anyone else?
>
>Renee

-- Hope this helps,

Belle

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