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Re: To Belle: PCOS and no IR?
From: Missy (anonymous@obgyn.net)
Mon, 31 Dec 2001 12:57:38 -0600 (CST)
Thank you Belle! You guys have been sooo helpful! I get it now or at
least I think I do. Your daughter is lucky to have such a smart mom!
Thanks, Missy
At Sun, 30 Dec 2001, Belle wrote:
>
>Yes, she is on Glucophage 1500 mg/day. She has just recently gotten a
>prescription for Glucpohage XR. We are preparing to fill it for the
>first time so we cannot report on how well that is going to work.
>
>I cannot emphasize enough that her fasting glucose was *normal*. In
>addition to that, her fasting insulin was in the normal range for the
>normal testing procedures. Her fasting insulin was 14ľU/ml when the
>normal range is 0 - 30ľU/ml (35 - 145 pmol/L). Since her
>endocrinologist was a specialist in insulin disorders, she recognized
>that the fasting level should ideally be below 10ľU/ml. Her regular
>pediatricians were unable to detect this, not because they were bad
>doctors but because they did not deal with insulin resistance. A blood
>value may be below disease levels but this does not mean that it is at a
>good level (see the explanation I had for glucose levels below). It was
>only when we tested her body's reaction to sugar (IGTT)that we
>discovered that she had higher than normal insulin levels after 1 hour
>of ingesting sugar (simulating a meal).
>
>Trying to watch your carb level is a wonderful thing to do. Since my
>daughter was only 13 at the time, we did not do carb counting for her
>because she was still growing and we did not want to risk losing any
>vitamins that she may get from certain fruits or veggies. Now that she
>is 15, we have been told to begin cutting out potatoes, white rice, etc.
>
>At Sun, 30 Dec 2001, Missy wrote:
>>
>>Thanks! Did your daughter have to go on insulin senitizing drugs then?
>>I've been trying to watch my carb and the type of carbs I intake. Is
>>that enough especially since my fasting glucose levels is in the ideal
>>range? Missy
>>
>>At Sat, 29 Dec 2001, Belle wrote:
>>>
>>>You can be thin and have PCOS. You can be thin and have IR. Fasting
>>>glucose means nothing. 199mg/dl is not normal. 200mg/dl is diabetic.
>>>Between 140 and 199 mg/dl is considered Glucose Intolerant. Fasting
>>>levels should be less than 120 mg/dl but ideally between 60 - 80mg/dl
>>>for a 8 - 12 hour fast. None-the-less, this does not have anything to
>>>do with insulin. A fasting insulin may help detect if you are IR but
>>>more likely, it will take a 2 hour Glucose Tolerance test with insulin
>>>levels (IGTT)to help make that determination.
>>>
>>>The truth of the matter is that doctors who are involved in PCOS
>>>research seem to feel that all women with PCOS would have IR if the
>>>tests were sensitive enough to detect it. The IGTT can only help
>>>diagnose IR because it is really only test for hyperinsulinemia. The
>>>actual test for insulin resistance is not done on women because of the
>>>costs. These are only done on research projects.
>>>
>>>Only about 1/2 of the women with PCOS are overweight according to some
>>>reports. IR can have nothing to do with weight. My daughter was always
>>>considered thin by her pediatricians to the point that this was
>>>commented on several times. When she started her period and did not
>>>regulate after a year, I took her in to the endo who did a a 2-hour IGTT
>>>on her and guess what? Extremely thin, hard to put on weight and ...
>>>diagnosed IR.
>>>
>>>At Sat, 29 Dec 2001, Missy wrote:
>>>>
>>>>I am not overweight nor do I have a
>>>>problem controlling my weight but I still wonder if I have PCOS, but how
>>>>could I if I am probably not IR?
>>>>
>>>>I read that only 10% of non-overweight women with PCOS have IR so how
>>>>does one explain PCOS in them? What caused it?
>>>>
>>>>My fasting glucose level was 77 with 65-199mg/dl being the normal range.
>>>>Does that mean anything? thanks, missy
>>>
>>>--
>>>Hope this helps,
>>>
>>>Belle
>>>
>--
>Hope this helps,
>
>Belle
>
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