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Re: aaagh! confusion over how hormones + insulin all affect each otherFrom: Sonnet (anonymous@obgyn.net)Sun, 9 Dec 2001 02:52:59 -0600 (CST)
I've got a great link for you, if you've got time to read through it: It is VERY long, and at times it can get a LITLLE technical although oveall it's very well written and easy to understand without any scientific background. It's just that our endocrine system is so complex, even the basics of it are enough to make your head spin! That article goes through a lot of the hormonal process in PCOS, in the ovary and aside from it. This clip is a great, short overview of PCOS and it points out the pathological process clearly putting the ovaries in their place as a tissue affected by PCOS, not the cause. (Although it also reminds us that not ovulating / PCO makes everything worse.) "If a teenage girl is overweight, is insulin resistant, and has inherited the trait that predisposes her to abnormal ovarian/adrenal function, the stage is then set for her to develop PCOS. The increased insulin resistance results in elevated serum insulin levels which then stimulates excess androgen production. This results in evidence of excess androgen production with facial hirsutism and/or acne. The excess androgen may also worsen the obesity, adding fuel to the fire. Increased androgen production interferes in normal ovulation. Women with this syndrome then stop ovulating (or probably never started in the first place). The increased androgen production blocks development of the follicles and so the ovary becomes "polycystic". The abnormal ovary then begins to produce increased amounts of androgen." It's complicated I know! But I do hope this helps!
-- Sonnet
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