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aaagh! confusion over how hormones + insulin all affect each otherFrom: anonymous (anonymous@obgyn.net)Sun, 9 Dec 2001 01:39:55 -0600 (CST)
Right. I'm confused. This syndrome is just way too complicated and I am so not a scientist. I'm just wondering if anyone minds filling in a few -well some probably quite fundamentally huge- gaps in my knowledge? Or maybe direct me to a good article that is not so much PCOS 101, but the next level up? OK, so I was looking at the results of the d chiro inositol 6-8 week study published in '99, and apart from being amazed at the results- I don't get how come the serum DHEAS in the d chiro inositol group can have been reduced by something like 47%? HOW? I thought it came from the adrenals and so sorting out the insulin stuff would reduce only ovarian production of androgens, among other important things. I mean, it's great and everything and I hope they hurry up and get it out- but how? why? How does this work? Also, I hate to bring this old question up again, but why does removal of the ovaries not help the hyperandrogenism aspect of pcos assuming one does not have excess adrenal androgens? I realise that PCOS is a lifelong disease, that the IR would still need dealing with, that any existing hair etc would remain, and there would probably be new problems that one would also need to deal with as a result. I know that as the oestrogen levels would be so much lower they wouldn't really be able to 'oppose' the remaining androgens - I suppose all this is reason enough. But I thought the insulin acted on the ovaries to increase ovarian production of testosterone and for that matter whatever the pituitary and hypothalamus are doing- I thought that would affect the ovaries. Is it to do with the adrenals getting out of balance? I thought the upshot would be maybe a far slower increase in HAIR comparable to what menopausal women seem to get. I suppose everything is just related to everything else and that's all there is to it. And another thing, is the male pattern weight gain thing an IR thing, basically, not so much an androgen thing? I mean the male pattern part. Am I just being stupid trying to draw all these lines between one aspect and another?
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