 |
 |
 |
|
|
|||
|
|
||||
|
||||
Re: Pain KillersFrom: Dona (anonymous@obgyn.net)Sun, 4 Nov 2001 19:30:02 -0600 (CST)
HI Randi, I found this abstract at a pharmacological website and thought this might help answere your question.I wanted to be sure I was correct in saying that the reason why you are supposed to let your doctor or dentist know you are on glucophage before dental treatment or surgery is because if we RX you a narcotic pain medication it can be contra indicated.Meaning you shouldnt be taking both because of drug interaction problems.For major medical surgeries were they might give you morphine:the glucophage and morphine can put excess stress on your renal function because they are both processed through the renal system.I believe that vicodin and other narcotic type pain relievers are also processed in our bodies in the same mannor (through the kidneys).Most doctors will tell you to stop taking glucophage a few days prior to surgery and will tell you when to resume.As far as the glucophage making the pain killer not work...I think that it dosen't do anything to the affects of the pain reliever.There is always a degree of pain involved with tooth extraction.Make sure you get plenty of rest and don't do any heavy lifting,don't rinse vigorously and please don't smoke as this can cause a dry socket which is very painful.You would be better off taking mortin for dental type pain as it is an anti-inflamitory and tend to work better than most narcotics for dental pain.I cut and pasted part of the abstract for you.hope this helps, Dona RDA (Registered Dental Assistant) Cationic Drugs: Cationic drugs (e.g., amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, and vancomycin) that are eliminated by renal tubular secretion theoretically have the potential for interaction with metformin by competing for common renal tubular transport systems. Such interaction between metformin and oral cimetidine has been observed in normal healthy volunteers in both single- and multiple-dose, metformin-cimetidine drug interaction studies, with a 60% increase in peak metformin plasma and whole blood concentrations and a 40% increase in plasma and whole blood metformin AUC. There was no change in elimination half-life in the single-dose study. Metformin had no effect on cimetidine pharmacokinetics. Although such interactions remain theoretical (except for cimetidine), careful patient monitoring and dose adjustment of metformin HCl and/or the interfering drug is recommended in patients who are taking cationic medications that are excreted via the proximal renal tubular secretory system. Other: Certain drugs tend to produce hyperglycemia and may lead to loss of glycemic control. These drugs include thiazide and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. When such drugs are administered to a patient receiving metformin HCl, the patient should be closely observed to maintain adequate glycemic control. In healthy volunteers, the pharmacokinetics of metformin and propranolol and metformin and ibuprofen were not affected when co-administered in single-dose interaction studies. Metformin is negligibly bound to plasma proteins and is, therefore, less likely to interact with highly protein-bound drugs such as salicylates, sulfonamides, chloramphenicol, and probenecid, as compared to the sulfonylureas, which are extensively bound to serum proteins.
>
|
|
Return to ![[ PCOS Discussion Forums ]](../../images/pcos_at_obgyn.gif)
Technical Problems: webmaster@obgyn.net
Last Updated: Mon May 19 17:01:29 2008
Women's Insurance Checklist from Auto Insurance Quote
home | medical professionals | women | industry | forums | international