Re: Any new info on PCOS?
From: Sonnet (anonymous@obgyn.net)
Wed, 17 Jan 2001 16:50:31 -0600 (CST)
Oh my gosh pauls you are the GREATEST. I love your info, thankyou so
much! I swear you're an inspiration to me :)
Sonn
At Wed, 17 Jan 2001, paula wrote:
>
>Researchers are thinking that PCOS is a "side illness" if Insulin
>Resistance (and yes they think this applies to those patients who are
>not currently manifesting the symptoms or test results of IR, they think
>that it is an eventuality with poor control). they are starting to
>believe it is connected to a genetic "mutation" or damage to a gene on
>chromosome 19. this gene sits right next to a gene for insulin
>reuptake. it is hypothisized that this causes a "misreading" in the
>code leading to a slightly different type of insulin being produced.
>(kinda like only one amino acid is different between normal insulin and
>insulin produced by a PCOS patient...im not saying that is the
>particular case, but it is like that...only a minor difference, but
>enough to throw off the body). apparently this causes a "cascade"
>effect in some patients causing their other hormones to respond
>strangely and either over or under produce. it is unlikely that
>isolating this gene will be beneifical in a direct sense because insulin
>is a chemical that is found all over the body, but if we can code for
>the exact sequence of this "string" of nucleotides, and we can pinpoint
>the differences between "normal" insulin and the insulin produced by
>people with this disease, it may be possible to produce a medication
>that either converts the insulin to normal insulin or tells our bodies
>this type of insulin is ok. (kinda like an insulin sensitizer, but more
>specific, which in theory would produce better results). the exact
>mechanisms are sketchy at best right now, but this seems to be the
>prevailing theory. there is also much research into other treatments
>and causes, this seems to just be the most likely at this point.
>
>(wow, i hope that mase sense=)
>love, paula
>
>--
>feel free to email me anytime at paulam74@hotmail.com
>
--
Email always welcome to: sonnet_fitz@hotmail.com
![[ PCOS Discussion Forums ]](../../images/pcos_at_obgyn.gif)