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PCOS research, Metformin treatment - USA From: Bells (anonymous@obgyn.net) Mon, 30 Oct 2000 21:15:54 -0600 (CST) Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Bells: "BCP's and Metformin - research from Finland" Previous message: Helen: "Re: Spent the day at the hospital...." Subset of Women With PCOS Respond to Treatment With Diabetes Drug -------------------------------------------------------------------------------- WESTPORT, Jul 12 (Reuters Health) - Metformin therapy reduces fasting -------------------------------------------------------------------------------- insulin levels and improves clinical symptoms of hyperandrogenism in -- -------------------------------------------------------------------------------- women with polycystic ovary syndrome and hyperinsulinemia, according to study results published in the June issue of Fertility and Sterility. Dr. Antoni J. Duleba, from Yale University School of Medicine, New Haven, Connecticut, and colleagues treated 39 patients with polycystic ovary syndrome and elevated fasting insulin levels with 12 weeks of oral metformin, at a dosage of 500 mg, three times a day. Four women became pregnant during treatment and were not included in the final analysis. By the end of the treatment period, fasting insulin levels had dropped by over 30%, while the glucose-to-insulin ratio increased by 33%, the authors determined. The group also observed an almost 40% decline in the free-testosterone index. Body mass index and the waist-hip ratio dropped slightly but significantly. "Clinical manifestations of hyperandrogenism also improved," the authors report, although improvement was influenced by baseline DHEA concentrations. Overall, the acne score dropped by 14%; the hirsutism score by 2.3%, and the average length of the menstrual cycle by 36%. Levels of insulin-like growth factor I showed little response to metformin treatment in women with normal baseline DHEAS concentrations, but the levels increased by 9.5% in women with high baseline DHEAS concentrations. "It appears that patients with adrenal hyperfunction represent a unique subpopulation of polycystic ovary syndrome," the authors write. Fertil Steril 2000;73:1149-1154. -- Thanks, Bells in Sydney, Australia Next message: Bells: "BCP's and Metformin - research from Finland" Previous message: Helen: "Re: Spent the day at the hospital...."

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