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Re: PDR for glucophage - THERE IS A TAGAMET interaction (belle)From: Michele (anonymous@obgyn.net)Wed, 19 Jul 2000 12:30:04 -0500 (CDT)
At Wed, 19 Jul 2000, Michele wrote: > >Belle did you check the pdr before saying it was okay to use tagamet >with met? Here is copy of the interactions: (I cut this right from the >pdr) It addresses other issues that the rest of you pcos'ers have. > >1. Medium Interaction between Tagamet (generic: cimetidine) and >Glucophage (generic: metformin) > >Cimetidine may significantly reduce the renal tubular secretion of >metformin. In one study, the area under the plasma concentration-time >curve for metformin was increased by 50% and the plasma clearance was >reduced by 27%. > >Particularly slow and cautious titration of metformin dosage is >recommended if these drugs must be used together. The maximal dose of >metformin should also be reduced. > >Here are some other things the PDR said: > >What is the most important information I should know about metformin? > > Avoid excessive alcohol intake while taking metformin. Together, >alcohol and metformin may increase the risk of lactic acidosis, a >condition that leads to death in 50% of cases. > Metformin does not usually cause hypoglycemia (low blood sugar). >Nevertheless, hypoglycemia may occur, as a result of skipped meals, >excessive exercise, or alcohol consumption. Know the signs and symptoms >of low blood sugar, which include headache, drowsiness, weakness, >dizziness, a fast heartbeat, sweating,tremor, and nausea. Carry candy >or glucose tablets to treat episodes of low blood sugar. > Call your doctor immediately if you experience a general discomfort or >sick feeling, unexplained sore or aching muscles, difficulty breathing, >unusual drowsiness, or abdominal discomfort. These may be early signs >of lactic acidosis, and your doctor may want to examine you. > >What should I avoid while taking metformin? > Alcohol should be avoided or only used in moderation during therapy >with metformin. Drinking alcohol regularly--or even once in a while in >large ounts--increases your chances of developing lactic acidosis, which >can be fatal. > > Call your doctor if you experience diarrhea, vomiting, fever, or >dehydration or if you decrease the amount of >food or liquid in your normal diet. You may need to stop your treatment >with metformin for a short amount of time until you are feeling better. > > Tell your doctor that you are taking metformin if you need to have >surgery or if you need x-rays or other imaging studies that require the >use of dyes containing iodide. > >What are the possible side effects of metformin? > > If you experience any of the following serious side effects, stop >taking metformin and seek emergency medical attention: >· an allergic reaction (difficulty breathing; closing of your throat; >swelling of your lips, tongue, or face; or >hives); or >· lactic acidosis (a general discomfort or sick feeling, unexplained >sore or aching muscles, difficulty breathing, >unusual drowsiness, or abdominal discomfort). > Other, less serious side effects may be more likely to occur. Continue >to take metformin and talk to your doctor if you experience >· nausea, vomiting, or diarrhea; >· abdominal bloating or increased gas production; or >· decreased appetite or changes in taste (metallic taste in your mouth). > Side effects other than those listed here may also occur. Talk to >your doctor about any side effect that seems unusual or that is >especially bothersome. > >What other drugs will affect metformin? > Before taking this medication, tell your doctor if you are taking any >of the following medications: > >. a diuretic (water pill) such as furosemide (Lasix), bumetanide >(Bumex), ethacrynic acid (Edecrin), torsemide >(Demadex), amiloride (Midamor), triamterene (Dyazide, Maxzide, >Dyrenium), spironolactone (Aldactone), hydrochlorothiazide >(Hydrodiuril), chlorothiazide (Diuril), chlorthalidone (Hygroton), >indapamide (Lozol), metolazone (Zaroxolyn, Mykrox), and others; >. (Thorazine), prochlorperazine (Compazine), promethazine >(Phenergan), and others >· an estrogen (Premarin, Prempro, Ogen, and others) or birth control >pill (Ovral, Lo-Ovral, Ortho-Novum, Triphasil, Levlen, Tri-Levlen, >Alesse, and others) >· a calcium channel blocker such as nifedipine (Adalat, Procardia), >verapamil (Calan, Verelan, Isoptin), >diltiazem (Cardizem, Dilacor XR), felodipine (Plendil), bepridil >(Vascor), amlodipine (Norvasc), and others; >· a steroid medication such as prednisone (Deltasone), >methylprednisolone (Medrol), dexamethasone(Decadron), and others; >· a thyroid medication (Synthroid, Levoxyl, Levothroid, and others), >· digoxin (Lanoxin, Lanoxicaps); >· procainamide (Pronestyl); >· quinidine (Cardioquin, others); > >***· CIMETIDINE (TAGAMET, Tagamet HB) or ranitidine (Zantac, Zantac 75); >**** > >· morphine (Astramorph, MS Contin, Roxanol, and others); >· trimethoprim (Proloprim, Trimpex, Septra, Bactrim); >· phenytoin (Dilantin); >· isoniazid (Nydrazid); or >· nicotinic acid or niacin (Nicobid, Nicolar, others). > You may not be able to take metformin, or you may require a dosage >adjustment or special monitoring if you are taking any of the medicines >listed above. > >Drugs other than those listed here may also interact with metformin or >affect your condition. Talk to your doctor and pharmacist before taking >any prescription or ver-the-counter medicines. > >At Wed, 19 Jul 2000, Belle wrote: >>I would not be surprised if this worked! Tagamet >>I have never seen it used as an anti-androgen >>At Tue, 18 Jul 2000, anonymous wrote: >>>my doctor just prescribed tagamet for hair problems, he said it is a >good anti androgen. > >-- >michele >
-- michele
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