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PDR for glucophage - THERE IS A TAGAMET interaction (belle)From: Michele (anonymous@obgyn.net)Wed, 19 Jul 2000 10:14:54 -0500 (CDT)
Belle did you check the pdr before saying it was okay to use tagamet with met? Here is copy of the interactions: (I cut this right from the pdr) It addresses other issues that the rest of you pcos'ers have. 1. Medium Interaction between Tagamet (generic: cimetidine) and Glucophage (generic: metformin) Cimetidine may significantly reduce the renal tubular secretion of metformin. In one study, the area under the plasma concentration-time curve for metformin was increased by 50% and the plasma clearance was reduced by 27%. Particularly slow and cautious titration of metformin dosage is recommended if these drugs must be used together. The maximal dose of metformin should also be reduced. Here are some other things the PDR said: What is the most important information I should know about metformin? Avoid excessive alcohol intake while taking metformin. Together, alcohol and metformin may increase the risk of lactic acidosis, a condition that leads to death in 50% of cases. Metformin does not usually cause hypoglycemia (low blood sugar). Nevertheless, hypoglycemia may occur, as a result of skipped meals, excessive exercise, or alcohol consumption. Know the signs and symptoms of low blood sugar, which include headache, drowsiness, weakness, dizziness, a fast heartbeat, sweating,tremor, and nausea. Carry candy or glucose tablets to treat episodes of low blood sugar. Call your doctor immediately if you experience a general discomfort or sick feeling, unexplained sore or aching muscles, difficulty breathing, unusual drowsiness, or abdominal discomfort. These may be early signs of lactic acidosis, and your doctor may want to examine you. What should I avoid while taking metformin? Alcohol should be avoided or only used in moderation during therapy with metformin. Drinking alcohol regularly--or even once in a while in large ounts--increases your chances of developing lactic acidosis, which can be fatal. Call your doctor if you experience diarrhea, vomiting, fever, or dehydration or if you decrease the amount of food or liquid in your normal diet. You may need to stop your treatment with metformin for a short amount of time until you are feeling better. Tell your doctor that you are taking metformin if you need to have surgery or if you need x-rays or other imaging studies that require the use of dyes containing iodide. What are the possible side effects of metformin? If you experience any of the following serious side effects, stop taking metformin and seek emergency medical attention: · an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); or · lactic acidosis (a general discomfort or sick feeling, unexplained sore or aching muscles, difficulty breathing, unusual drowsiness, or abdominal discomfort). Other, less serious side effects may be more likely to occur. Continue to take metformin and talk to your doctor if you experience · nausea, vomiting, or diarrhea; · abdominal bloating or increased gas production; or · decreased appetite or changes in taste (metallic taste in your mouth). Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. What other drugs will affect metformin? Before taking this medication, tell your doctor if you are taking any of the following medications: . a diuretic (water pill) such as furosemide (Lasix), bumetanide (Bumex), ethacrynic acid (Edecrin), torsemide (Demadex), amiloride (Midamor), triamterene (Dyazide, Maxzide, Dyrenium), spironolactone (Aldactone), hydrochlorothiazide (Hydrodiuril), chlorothiazide (Diuril), chlorthalidone (Hygroton), indapamide (Lozol), metolazone (Zaroxolyn, Mykrox), and others; . (Thorazine), prochlorperazine (Compazine), promethazine (Phenergan), and others · an estrogen (Premarin, Prempro, Ogen, and others) or birth control pill (Ovral, Lo-Ovral, Ortho-Novum, Triphasil, Levlen, Tri-Levlen, Alesse, and others) · a calcium channel blocker such as nifedipine (Adalat, Procardia), verapamil (Calan, Verelan, Isoptin), diltiazem (Cardizem, Dilacor XR), felodipine (Plendil), bepridil (Vascor), amlodipine (Norvasc), and others; · a steroid medication such as prednisone (Deltasone), methylprednisolone (Medrol), dexamethasone(Decadron), and others; · a thyroid medication (Synthroid, Levoxyl, Levothroid, and others), · digoxin (Lanoxin, Lanoxicaps); · procainamide (Pronestyl); · quinidine (Cardioquin, others); ***· CIMETIDINE (TAGAMET, Tagamet HB) or ranitidine (Zantac, Zantac 75); **** · morphine (Astramorph, MS Contin, Roxanol, and others); · trimethoprim (Proloprim, Trimpex, Septra, Bactrim); · phenytoin (Dilantin); · isoniazid (Nydrazid); or · nicotinic acid or niacin (Nicobid, Nicolar, others). You may not be able to take metformin, or you may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above. Drugs other than those listed here may also interact with metformin or affect your condition. Talk to your doctor and pharmacist before taking any prescription or ver-the-counter medicines.
At Wed, 19 Jul 2000, Belle wrote:
>I would not be surprised if this worked! Tagamet
-- michele
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