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Re: Subset of women with PCOS respond to treatment with diabetes
From: gayle (anonymous@obgyn.net)
Thu, 13 Jul 2000 16:53:27 -0500 (CDT)
Sorry for my ignorance but can anyone explain what the following
paragraph of this publication actually means please? What is the DHEAS?
- Thanks
Levels of insulin-like growth factor I showed little response to
metformin treatment in women with normal baseline DHEAS concentrations,
but the levels increased by 9.5% in women with high baseline DHEAS
concentrations
At Thu, 13 Jul 2000, Bruce wrote:
>
>At Thu, 13 Jul 2000, Kay wrote:
>>
>>Thank You Bruce! This one is printed out for my doc!
>>Kay
>>
>You're welcome.
>
>Note that the docs appreciate receiving peer-reviewed published studies
>such as cited below from the latest Fertility & Sterility issue. It
>carries a lot more crediability then simple clips from the newspaper or
>a copy of a web page.
>
>Best
>Bruce
>
>>At Thu, 13 Jul 2000, Bruce wrote:
>>>
>>>Jul 12 - Metformin therapy reduces fasting insulin levels and improves
>>>clinical symptoms of hyperandrogenism in women with polycystic ovary
>>>syndrome and hyperinsulinemia, according to study results published in the
>>>June issue of Fertility and Sterility.
>>>
>>>Dr. Antoni J. Duleba, from Yale University School of Medicine, New Haven,
>>>Connecticut, and colleagues treated 39 patients with polycystic ovary
>>>syndrome and elevated fasting insulin levels with 12 weeks of oral
>>>metformin, at a dosage of 500 mg, three times a day. Four women became
>>>pregnant during treatment and were not included in the final analysis.
>>>
>>>By the end of the treatment period, fasting insulin levels had dropped by
>>>over 30%, while the glucose-to-insulin ratio increased by 33%, the authors
>>>determined. The group also observed an almost 40% decline in the
>>>free-testosterone index. Body mass index and the waist-hip ratio dropped
>>>slightly but significantly.
>>>
>>>"Clinical manifestations of hyperandrogenism also improved," the authors
>>>report, although improvement was influenced by baseline DHEA
>>>concentrations. Overall, the acne score dropped by 14%; the hirsutism score
>>>by 2.3%, and the average length of the menstrual cycle by 36%.
>>>
>>>Levels of insulin-like growth factor I showed little response to metformin
>>>treatment in women with normal baseline DHEAS concentrations, but the
>>>levels increased by 9.5% in women with high baseline DHEAS concentrations.
>>>
>>>"It appears that patients with adrenal hyperfunction represent a unique
>>>subpopulation of polycystic ovary syndrome," the authors write.
>>>
>>>Fertil Steril 2000;73:1149-1154.
>>>
>>>-Westport Newsroom 203 319 2700
>>>© 2000 Reuters Limited. All rights reserved. Republication or
>>>redistribution of Reuters content, including by framing or similar means,
>>>is expressly prohibited without the prior written consent of Reuters.
>>>Reuters shall not be liable for any errors or delays in the content, or for
>>>any actions taken in reliance thereon.
>>>
>>>--
>>>Bruce Speyer, CTO Home of OBGYN.net
>>>MediSpecialty.com The Universe of Women's Health
>>>512-835-1111 ext 227 A Physician Directed Network
>>>512-835-6112 fax, 512-632-3455 mobile http://www.obgyn.net
>>>EMAIL: anonymous@obgyn.net
>>>
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