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Re: Metformin Vs. Avandia
From: A (anonymous@obgyn.net)
Tue, 27 Jun 2000 20:48:40 -0400
Belle..
Once again, thanks so much for the info! Looking forward to what the new RE
thinks about these meds.
Thanks,
:-) Alexis
Belle wrote:
> Here is the information that is from the PCOSupport board at
> http:/www.pcosupport.org. I do want to mention that the main difference
> is that met has been tested and proven to help women with PCOS. Avandia
> has not. Having said this, I will be the first to admit that if the met
> does not totally control my insulin problem, I will be willing to *add*
> Avandia to the metformin.
>
> metformin also lowers blood lipid levels and is the only one with the
> side effect of weight loss in some people. metformin is synthasized by
> the kidneys while the Avandia is cleared by the liver.
>
> -----
>
> Metformin (Glucophage®). Metformin improves both glucose tolerance and
> insulin sensitivity. It is approved by the FDA as a treatment for
> diabetes. Metformin is prescribed under the brand name Glucophage made
> by Bristol-Myers Squibb in 500mg, 850mg and 1000mg tablets. Glucophage
> is given 2-3 times daily with a meal. If a dose is missed or a meal is
> skipped take the next dose at the following meal. Do not double the
> dose at the next meal. Approximately 30 % of patients started on
> Glucophage will experience gastrointestinal symptoms (diarrhea, nausea,
> vomiting, abdominal bloating, flatulence, and loss of appetite). These
> symptoms are usually temporary (1-4 weeks) and will disappear during
> continued therapy. It is advisable for new patients to initiate therapy
> slowly to minimize the gastrointestinal side effects.
>
> Pioglitazone (ACTOS®). Pioglitazone works primarily by improving
> insulin sensitivity and glucose tolerance. The FDA approved the drug in
> July 1999 for use in type 2 diabetes. Pioglitazone is available under
> the brand name ACTOS, made by Takeda Pharmaceuticals and co-marketed by
> Eli Lilly. ACTOS is available in 15mg, 30mg, and 45mg tablets. It is
> taken once daily with or without food. There were few notable side
> effects in clinical trials. Another added benefit seen with
> Pioglitazone is the reduction of triglyceride levels. Periodic liver
> function tests are recommended for the first year of therapy.
>
> Rosiglitazone (Avandia®) made by SmithKline Beecham works in a similar
> fashion to Rezulin® and ACTOS® by improving insulin sensitivity. Avandia
> is available in 2mg, 4mg and 8mg tablets. Avandia is usually taken
> twice daily. A low incidence of side effects was noted in clinical
> trials. Periodic liver function tests are recommended for the first
> year of therapy.
>
> At Mon, 26 Jun 2000, A wrote:
> >
> Anyway, I
> >looking at Met as a possibility although I've been reading quite a bit
> >about Avandia lately and am somewhat confused. Can someone explain the
> >differences and what each of them are really supposed to do?
> >
> >Thanks so much!!
> >:-) Alexis
>
> --
> Hope this helps,
>
> Belle
>
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