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Re: Introduction and historyFrom: Sallie (anonymous@obgyn.net)Wed, 15 Mar 2000 14:55:33 -0600 (CST)
>Salle- have you done research on the potential dangers/side effects of inositol? Do you know whether it causes any problems for women trying to get pregnant? > Yes, I have done tons of research on inositol. Inositol is considered part of the B complex (about 100mg is included in Bcomplex supplement) although it is not really a vitamin because your body can make it on its own. I give my daughters 1000 -1500mg every morning on an empty stomach. Your body probably makes this much every day and you consume it in foods. Diabetics are known to be deficient in inositol or actually in how it is probably altered or blocked in some way. I think it is the same in PCOS. When inositol interacts with insulin it forms an inositol gylcan that causes the wrong hormones to be made. I think it also might have something to do with, HGH human growth hormone and the IGF, insulin like growth factor. Inositol deficiency is associtated with hair loss and slow growth. Inositol can be depleted in the body from a diet high in sugar and refined carbohydrates, excessive caffeine consumption and stress. By taking inositol on an empty stomach it prevents interaction with insulin and digestive enzymes and can therefore enter into cells without being altered. I don't know what INSMED's drug INS1 is in relation to plain inositol but I think it might be that it is a form of inositol that the body should make. Hopefully by taking inositol on an empty stomach the body can make it right without insulin changing it. I could get really technical here explaining the different forms of inositol and phosphates but that would be writing a book so I will refer you to the books that I have read and the research studies. Here is a web site that is about a new book and product called IP6. It is the main book that I learned much about inositol. I don't give them IP6+insoitol (a product called Cell Forte`) at least not all the time. I just started this month alternating it with the inositol every few days. http://www.ip-6.net/secondpage.html Here is INSMED's web site http://www.insmed.com/ At the IP6 website there is a link to PUBMED where you can put PCOS or inositol and PCOS to read research studies. I also find alot just leaving PCOS out and researching insulin resistance or diabetes. Also read about inositol in Dr. Atkins Vita Nutrient Solution. As far as whether it is safe to take while pregnant, that is something you would have to decide. I would and I would recommend my daughters to. I would say to ask your doctor but I doubt they would know anything about inositol and their standard line would be you should not take it because that is what they say when they don't know. All you can do is read,read,read and make up your own mind. It is not known to be toxic at any dosage from anywhere I have read about it. Diabetics are cautioned about taking it because it could alter the amount of insulin or insulin sensitizing drugs you need. It would lessen the amount. So if you are taking metformin I would check your blood sugar and see if you might need less. If I was giving my daughters metformin I would probably not give any inositol also or I would only give them about 500mg of metformin. I hope that I have not confused you more but there is so much to read that I could not possibly explain it all here.
-- Sallie
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