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Re: Metaformin-Glocophage Dosages

From: =?iso-8859-2?q?Zalányi Sámuel ?= (anonymous@obgyn.net)
Fri, 18 Apr 2003 21:48:51 +0200

Hi MElissa,

This is the $64K question (I have put it several times on this board) and nobody can meaniongfully answer it. Here is my opinion: as metformin (sp!) is a diabetes drug, its maximum dose should be considered for frank diabetics only. On the other hand, PCOS with insulin resistance in the background is only the antechamber of diabetes, lower doses should suffice. I consider particularly meaningless to increase the dose within weeks, because to see the effect (on ovulation) of a particular dose level, you should wait a month as a minimum (for a month is needed to see wether you ovulated or not). Taking into account the fact that the effect of metformin on the ovulatory process is indirect, I have kept patients on a certain (low) dose for 3 mo at least, before increasing it. Any other opinion is welcome

Sam

> Why do Dr's put people are certain strengths of Metformin or
> Glucophage?? I understand why they gradually increase the dosages, cause
> already at a low dose you have what I call (TBS) "toilet bowl syndrome"
> Then they increase as your body gets used to the meds. But why are some
> on 1000mg, 2000mg or 2500mg a day??
>

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