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Re: Pregnancy and progesteroneFrom: anonymous@obgyn.netSun, 9 Mar 2003 18:34:12 -0600 (CST)
BJ, I don't mean to sound antagonistic. I realize this list has seen strife over this issue before, searching the archives. But I do seek knowledge and advice, and apologize if you saw this as an attack. Yours is just one of several names that comes up when I search the archives for P4 creams, and you often include references to these websites.
>At Sun, 9 Mar 2003, BJ wrote:
>No, I'm not a rep for any progesterone cream company. Do >you assume everytime a poster mentions a pharmaceutical >that they represent the drug company who sells it? Not at all. But when I search the archives for other posts by the same author, and find that these websites are mentioned over and over again *without* a disclaimer that makes it clear the poster does not have any financial interest in the company in question, I have to wonder. Since you have now made it clear that you are not associated with any of these companies in a way that leads to profit for yourself, you have my apologies.
>I use this reference because of the information provided >on the site, not because Arbonne sells a product which I >have never used by the way). The references are to >websites, not email addresses. It is clear that you see the information at these sites as valid medical advice. Since your email address is from a company that makes products used in interventional cardiology, I am assuming you might have some education in subjects such as pharmacology and physiology, and can perform critical evaluations of the validity of these claims. I am not seeing much in the way of studies from peer-reviewed medical and scientific journals at these sites, but lots of patient testimonials. My own search of the literature shows articles that support the use of transdermal P4, as well as ones that find very little absorption from the skin. Were clinical trials done by these companies to prove the effectiveness of their products, and could you post them to the list? I would consider using transdermal P4 in place of the more inconvenient vaginal P4 suppositories I am using now, if I could find enough verifiable evidence (not just testimonials) to support it. In fact, I am leaving for a medical conference in California and have been very concerned about how I will keep my suppositories refrigerated on the trip, and have considered switching to Prometrium capsules for this reason. If I can find a safe and effective cream that can do the same, along with a dosing protocol that allows me to convert my current suppository dose to an equivalent transdermal dose, this might be an option with fewer side effects and wear and tear on my liver. Any advice here?
>You are absolutely correct about the other forms I am glad to see we agree on this issue, since this observation is based in fact.
>The question specifically addressed use of progesterone >during pregnancy and that is why I made specific Again I agree wholeheartedly. At the same time, I would also warn that inappropriate use of USP bio-identical P4 in incorrect doses or at the wrong times of the menstrual cycle, can also inhibit ovulation or interfere with an established pregnancy. So I am concerned when women want to self-prescribe these creams, especially if there is no standard table or nomogram with which to calculate the appropriate dosing. If you have a link to one of these, I would also like to see it.
>It's time and space consuming to repeat all this info Again, not to be antagonistic, but why do you imply that my posts about progesterone take up valuable space, but yours do not? I am relatively new to this board, while you are a regular poster. I think the bandwidth I have taken up is very minimal compared to that used by you. Is my viewpoint less valid than yours? Have you found any factual errors in the posts I have made to this board or the general PCOS board?
>Hopefully women will do some reading and talk to a >pharmacist or doctor about it. >BJ Once again, I have no argument with this statement, and I sincerely hope that women will indeed talk to licensed medical professionals before making decisions about these--or any--OTC or prescription products. Cassandra
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