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Re: Natural progesterone dosageFrom: Victoria (anonymous@obgyn.net)Sun, 29 Dec 2002 22:30:50 -0500
You'll get places that will tell you they do ok, but there is a link on that progesterone page where compounding pharmacies were checked, and they weren't very accurate. It depends on whether or not you're willing to take the risk. http://www.docguide.com/news/content.nsf/news/8525697700573E1885256C3E0070936D?OpenDocument&c=&count=10&id=6C35C46F271652E485256 8CF00464567&abd=yes ACCP: Pharmacy Compounding Prone to Error, FDA Finds By Roberta Friedman, PhD Special to DG News SAN FRANCISCO, CA -- September 23, 2002 -- Pharmacists that compound their own versions of approved drugs do not always create the correct dosage, according to a study by the United States Food and Drug Administration (FDA) reported September 21st at the 31st Annual Meeting of the American College of Clinical Pharmacology (ACCP). Vaiyapuri Subramaniam, Pharm.D., of the FDA's Center for Drug Evaluation and Research in Rockville, Maryland, presented a sampling of 12 pharmacies that advertise and make compounded products available for sale over the internet. The FDA study selected 29 samples based on commonly used agents, and on the potential for health consequences if mistakes are made. Ten of the 29 samples failed, with nine testing sub-potent. One sample was contaminated. More than half had less than 70 percent of the potency stated on labelling. Three other samples failed an initial test, but, because inadequate amounts were left for re-testing, they were not scored as failures. Tests were carried out at an FDA laboratory with assays specific for dosage form and testing requirements of USP/NF or NDA/ANDA. By comparison, one to two percent of drugs from manufacturers fail to meet standard. Some compounded progesterone samples also failed, both as capsules and as injectables.
-- Victoria
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