PCOS-MEDICATION Messages for November, 2002: Re: Dr Sam

Re: Dr Sam - 2 questions

From: Renee (anonymous@obgyn.net)
Fri, 22 Nov 2002 07:58:40 -0800

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Maybe in reply to: jodi: "Dr Sam - 2 questions"

Actually, it's not quite that simple in the U.S. A generic has the same active ingredient, in the same amount, true. However, the binders, fillers, and coatings may differ. That can affect the disolving and absorption rate and amount of the drug. The FDA's standard for therapeutic equivalence allows for a range of 80-125% the bioavailability of the brand drug. In other words, you can get 80-125% of the drug into your blood stream compared to how much you get into your blood stream with the brand drug. For many drugs this variation doesn't matter. For others, it may (especially ones that need careful titration). The changes in absorption (the filler, coating, binders, etc.) may result in the drug entering your system faster or slower than it does with the brand name, which may affect some people.

While these changes may not matter for most people, for most drugs, in other cases it does matter. So, if someone doesn't respond well to the generic after being on the brand name, they may be sensitive to the distance and should go back.

Renee

Zal·nyi S·muel wrote: >
> Hi Jodi,
>
> Answers
> 1. By definition a generic is the SAME substance, with the SAME pharmacologic properties (absorption, metabolism etc.), therefore I don't beleive they may have different action.

>
> Sam

-- -------------- Renee Cordrey, MSPT, MPH, CWS

---
Dwell in Possibility.
--Emily Dickenson

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