PCOS-MEDICATION Messages for November, 2002: Re: Dr Sam

Re: Dr Sam - 2 questions

From: =?iso-8859-2?q?Zalányi Sámuel ?= (anonymous@obgyn.net)
Fri, 22 Nov 2002 06:14:55 -0800

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Hi Jodi,

Answers 1. By definition a generic is the SAME substance, with the SAME pharmacologic properties (absorption, metabolism etc.), therefore I don't beleive they may have different action. Brand-name producers try to project a picture of inferiority of generics, as the latter are cheaper (sometimes substantially) therefore ripping the patent owners of huge extra profits. There is an easy way to prove this: try to switch back to brand-name product. Naturally I do not speak of inferior products or simple fakes. Subanswer: I am no dermatologist. 2. There are controversies in the use of hormonal contraceptives. The earlier ones (50 mcg ethynyl-estradiol or more) were proven to have diabetogenic properties (i.e. deteriorating the metabolism of glucose) and increasing blood-pressure. New products (30 mcg or less) seem to be rid of the metabolic side-effect (which I still doubt). Fact: they are switching off ovulation (via the pituitary) and decreasing the levels of FSH/LH which is a bonus. The trick is, when you stop them your symptoms turn back in full force. Antiandrogenic OCs block the effect of testosterone on its receptor improving androgen aspects of PCOS. For your info

Sam

> 1. I was taking generic metformin and had a relapse of PCOS symptoms.
> All the progress I made on the Glucophage went away. My periods
> stopped, my hair started falling out, my body hair was coming back AND
> getting worse. I have had my doctor (a new doctor becuase we moved)
> prescribe the name brand glucophage again, because I have heard from
> other women the switching to generic didn't work as well for them. My
> doctor thinks this could be the reason, however she warns me that
> sometimes the glucophage just does stop working. Have you ever heard of
> this happening? I was on name-brand glucophage for a little over a year,
> then was on generic for about 6 months. I have been taking 2000mg,
> 1000mg with breakfast and 1000mg with dinner. (Sub question - I have
> lost a LOT of hair. Can hair lost from PCOS grow back when the problem
> is corrected, or is it gone for good?)
>
> 2. My new doctor has told me that from a PCOS standpoint, there is no
> good reason to be on birth control pills. She said that the ovarian
> cysts they help to suppress are not the same as the cysts we have with
> PCOS. Since the BCPs don't do anything about our insulin problems, the
> insulin is still acting on the ovary, regardless of what the BCPs are
> doing to shut off the pituitary gland's single to ovulate. Have you
> ever heard this before? Every doctor I have ever seen has said BCPs are
> good for PCOS because they make our cysts go away and our ovaries settle
> down. But if my new doctor's belief is true, it would explain why BCPs
> never seemed to provide me with any symptom relief whatsoever, aside
> from regular induced bleeds. I never had any relief from PCOS until I
> went on Glucophage.
>
> Just wondering what your opinions on these things are.
>
> - jodi
>

Next message: anonymous@obgyn.net: "Re: PCOS-MEDICATION digest 1009"
Previous message: Catherine: "Re: Has anyone used a med for weight loss?"
Maybe in reply to: jodi: "Dr Sam - 2 questions"
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