PCOS-MEDICATION Messages for September, 2002: Re: Articles: Metformin, Preconception and Pregnancy

Re: Articles: Metformin, Preconception and Pregnancy

From: Pat (anonymous@obgyn.net)
Wed, 11 Sep 2002 18:57:22 -0500 (CDT)

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Well, this is true...no major, harmful effects. But, these can't be long term studies, so long term effects are what I am also thinking of. It makes logical sense that if they improve the cells ability to use glucose and insulin, they can be very effective, and very useful. So, my personal opinion is it is worth the risk. But, folks need to decide for themselves the benefits and potential risks when undertaking any such ong term treatment.I am quite encouraged by the positive studies. Pat Sonnenstuhl, ARNP, CNM, MS PCOS Support Editorial Advisor PCOS Pavilion http://www.obgyn.net/pcos/pcos.asp http://www.midwivesofwa.org/pcos.htm http://www.midwivesofwa.org//pcosarticles.htm

>
>>If you have PCOS or severe Insulin Resistance, the trend seems to be
>towards continuing with Metformin into the pregnancy, and sometimes
>through the pregnancy. Women that are diabetic might also take
>Metformin throughout the pregnancy. There has not been enough good
>research to clarify the total safety long term, but nothing serious has
>shown up.<
>
>Actually, Pat, most of the research done with met and pg women has shown
>no harmful effects on the baby. Almost all of the research to date
>(with the exception of Dr. Glueck) has been done in Europe on pg women
>who are also diabetic. Unbeknownst to many, the FDA often uses Europe
>as a guinea pig of sorts and studies the results from their drug trials,
>making note of the successes and failures. Once the FDA decides that it
>hasn't hurt anyone in European studies, they often change the
>classification of a medication or approve of its prior off-label use.

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In reply to: Sue: "Re: Articles: Metformin, Preconception and Pregnancy"
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