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Re: Articles: Metformin, Preconception and PregnancyFrom: Sue (anonymous@obgyn.net)Wed, 11 Sep 2002 09:09:30 -0500 (CDT)
>If you have PCOS or severe Insulin Resistance, the trend seems to be towards continuing with Metformin into the pregnancy, and sometimes through the pregnancy. Women that are diabetic might also take Metformin throughout the pregnancy. There has not been enough good research to clarify the total safety long term, but nothing serious has shown up.< Actually, Pat, most of the research done with met and pg women has shown no harmful effects on the baby. Almost all of the research to date (with the exception of Dr. Glueck) has been done in Europe on pg women who are also diabetic. Unbeknownst to many, the FDA often uses Europe as a guinea pig of sorts and studies the results from their drug trials, making note of the successes and failures. Once the FDA decides that it hasn't hurt anyone in European studies, they often change the classification of a medication or approve of its prior off-label use.
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