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Re: PCOS and SpironolactoneFrom: Sue (anonymous@obgyn.net)Thu, 25 Jul 2002 08:28:29 -0500 (CDT)
>Could being at the low end of the Testosterone range cause her hormones to be out of balance, thus causing the weight gain? Anybody have any input? Thanks.< It's more likely that her weight gain is caused by her insulin resistance, which she's no longer treating (she was when she was on Glucophage). The testosterone levels are directly linked to insulin levels, unless you're treating it with another medication (which you are, the spironolactone). So while her testosterone is in a fine range, her insulin levels are probably out of this world. If she's not being treated by a RE, she really should be--a pediatrician or GYN are likely not to be well-enough versed in this condition to know the most current forms of treatment and how best to treat her. If she had a reaction to the Glucophage, know that there are two other insulin sensitizers out there (neither of which will facilitate weight loss like Glucophage), but there are other ways to lower her insulin levels. If she doesn't treat this, it's highly proabable that she'll continue to gain weight and add the other health problems that are so common with PCO. And if her insulin resistance isn't treated for a significant length of time, she risks becoming diabetic altogether--the pancreas only has so much insulin to squirt out, and if that "lifetime cap" is reached before the end of one's life, there's no place else to get the insulin except through artificial means (injections). The pancreas just quits. HTH
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