Re: Dr. Sam? A question for you.
From: =?iso-8859-2?q?Zalányi Sámuel ?= (anonymous@obgyn.net)
Thu, 27 Jun 2002 23:06:10 +0200
Hi Pat,
I have to defend the pharma industry. Natural progesterone (P) is hardly absorbed from the GI tract. It has been extensively researched in the early years of endocrinology (Selye, 1935) and turned out to be useless for human application. Therefore it was a tremendous breakthrough, when German organic chemists succeeded to synthetise the first orally active estrogen (ethynil-estradiol) and gestagen. The ones (norethisterone among them) that were applied in oral contraceptives were synthetised later by C. Jerassy. Only the physiochemical manipulation (micronization) of P rendered it absorbable from the GI tract. And still it is less active than the synthetic derivatives (therefore not available as a conttraceptive). And porvera is a very good synthetic choice being a close relative of the natural compound: medroxy-progesterone-acetate.
For your info
Sam
> I am not Dr. Sam, but I have used Progesterone Cream quite successfully
> as a substitute for Provera. As a Woman's Health Care provider, I work
> with women to find combinations that work best for them. Micronized
> progesterone in tablet form, and prescription progesterone cream have
> been more researched and more consistent in amount. The progesteone
> cream you can buy over the counter is less reliable, and the % of
> progesterone will vary. The problem is these are 'natural' products,
> have probably been less well researched, and there isn't the same money
> to be made with natural progesterone, as there is to be made with
> synthetics. Sorry to be so tough on the pharmaceutical companies, but I
> belive this to be so. For many years we were limited to synthetic
> progestin with no natural products available. It has only been through
> consumer demand that we now have a wide variety of products, and finally
> in many instances, natural progesterone is being used more and more
>
> Pat Sonnenstuhl, ARNP, CNM, MS
> Balanced Eating Support
> http://home.attbi.com/~cnmpat/favlowcarbsites.htm
> http://home.attbi.com/~cnmpat/siteindex.htm
> PCOS Support
> http://www.midwivesofwa.org/pcos.htm
> http://www.midwivesofwa.org//pcosarticles.htm.
>
> >Hello Dr. Sam. :) I just wanted to know what your thoughts were on
> >natural progesterone creme. I've read a bit about it over the past few
> >days and was just curious to how you felt about this form of
> >treatment(in general).
> >
> >Thanks for your thoughts and ideas!
> >Tangelo ;)
>
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