Re: quitting Glucophage????!!!
From: =?iso-8859-2?q?Zalányi Sámuel ?= (anonymous@obgyn.net)
Sun, 31 Mar 2002 22:45:12 +0200
Hi Nancy,
Your reasoning is correct. The effect of metformin reducing miscarriage rate outwieghs the risk of increased rate of neural tube defects. Besides, taking extra 800 mcg of folic acid counteracts this latter risk.
For your inro
Sam
> My doctor has instructed me to stop taking the glucophage I was taking.
> >He said I should have stopped as soon as I tested positive for pregnancy
> >3 weeks ago, however, I guess I slipped through the cracks and they
> >forgot to tell me to stop. I am worried about 2 things...
> >
> >First, he said that being on the drug for 7+ weeks should have done no
> >harm, but then why take me off? Could *any* harm have been done by
> >taking this drug 7 weeks in? If so, what kind of harm?
> >
> >And second, I have read that being on glucophage for the first trimester
> >greatly reduces the chances of early miscarriage. From what I
> >understand, there have not been enough studies to say conclusively that
> >there is *NO* risk of birth defects, however, that is the direction the
> >class B studies are leaning at this early stage, right? If so, don't the
> >greatly reduced chances of miscarriage (30-50% chance w/o glucophage
> >reduced to 5-11% with, according to several studies I have read)
> >outweigh the VERY remote possibilities of any defects? Or, is the stuff
> >I am reading about the miscarriage rates on and off glucophage
> >INCORRECT?? It is so hard to find out what is true and what is myth! My
> >fertility doctor said that stopping glucophage has NO impact at all on
> >miscarriage rates, but that is just exactly the opposite of what I read
> >almost everywhere I look. Can someone clarify???
> >
> >I am scared stiff to stay on the drug and cause harm to my baby and also
> >about miscarriage if I stop! My doctor said that now that we have seen
> >the heart beat, my odds of miscarriage are less than 5%, same as a
> >non-PCOS person... What do you think?
>
> Nancyleigh
>
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