PCOS-MEDICATION Messages for March, 2002: Re: Pregnenolone

Re: Pregnenolone

From: =?iso-8859-2?q?Zalányi Sámuel ?= (anonymous@obgyn.net)
Thu, 7 Mar 2002 20:22:21 +0100

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<boodles77@netzero.net (Deborah)> 2002.03.06. 00:06:29 -6h-kor írta:

> Hi Jane...
>
> I just had my hormone levels tested...this is probably the fourth or
> fifth time. But the reason behind the testing is that my doctor would
> like to put me on Pregnenolone. From what I understand, it is the
> precursor to the production of all the human steroid hormones -- DHEA,
> Progesterone, Estrogens, Testosterone, Cortisone, Cortisol, and
> Aldosterone. It is also supposed to balance the hormone levels. For
> me, I have an elevated testosterone levels... I don't know about DHEA
> (I'll find out soon!), but if this drug is supposed to BALANCE hormones,
> it could be very beneficial!
>
> Any other women have success or failure with pregnenolone? I'd be
> interested in hearing!
>

I maybe somewhat backward, but the problem is not the lack of pregnenolone but the block between DHEA and the later products (progesterone, estradiol). Thgerefore the elveated DHEA(S) levels and also testosterone (t) is elevated because DHEA is shunted towards t instead of E,P. I would like to have a more detrailed explanation for this from your dr (if there is any). This balancing hormone levels is just a blah blah. The entire female endocrine system is about shifting between different hormones during the cycle. The most relevant is the shift between estradiol and progesterone, the former being dominant during the first half, the other during the second half of the cycle. There is nothing such as balancing exact on the tight rope... For your info

Sam

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