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Re: PCOS and it's cause

From: =?iso-8859-2?q?Zalányi Sámuel ?= (anonymous@obgyn.net)
Thu, 7 Mar 2002 20:13:50 +0100


<anonymous@medispecialty.com (Teresa)> 2002.03.05. 22:08:06 -6h-kor írta:

> A while back Dr. Sam answered a post and stated that PCOS is a genetic
> disease of the insulin receptors. I hadn't heard this before.
>
> Is this a new discovery?

It isn't. It was suspected for decades that there must be a connection between PCOS and diabetes (b/c many PCOSers became diabetics in later life). Then some 10y ago PCOSers turned out to be insulin resistant (IR) and some ys later the faulty insulin receptor was discovered. Because the insulin receptors are faulty, they do not work properly. Therefore not enough sugar enters into the cells. The pancreas tries to compensate for this by churning out more insulin, than it exhausts and type2 diabetes ensues. All the rest is a consequence of the faulty insulin receptors (b/c they are present on every cell, every cell reacts differently to the lack of glucose and/or high levels of insulin). For your info

Sam >
> The books I have read say PCOS is the result of a hormone imbalance
> caused by a disorder in the endocrine system. Dr. Sam made it sound
> like the receptors are bad and the rest falls into place. People seem
> to be vague about the causes and then all of a sudden I hear something
> so specific and it makes sense. I was wondering if this is a new
> discovery. Thanks.
>




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