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Re: Glucophage XR==GI side effects....help!!From: mrsdoubtfyre (anonymous@obgyn.net)Fri, 22 Feb 2002 10:06:03 -0600 (CST)
At Mon, 18 Feb 2002, =?iso-8859-2?q?Zalányi wrote: > > <madeline808@aol.com (Maddy)> 2002.02.17. 22:52:40 -6h-kor írta: >Come on Maddy, > >If you have GI side-effects, then the substance is absorbed. It is only the outer shell you find 9-12 h later in stool. Regular metformin is even worse as for side-effects. >For your info > >Sam > >> Hi there-- >> I'm 25 and just started on Glucophage XR. I have been taking 500 mg. >> for about a week, and I am having pretty awful GI upset....diarrhea etc. >> Also, i saw someone else with this problem, the capsules themselves >> sometimes come out, but like nine to twelve hours later!!! Someone >> replied that the medication itself is absorbed, but how can that be? I >> actually checked one of the undigested capsules and there was a white >> substance inside. Does anyone think regular Glucophage is easier to >> digest, etc. than the Glucophage XR? I have been taking it with my >> dinner....so I don' tknow what to do about the stomach upset and how >> long to stick it out. I want to get up to 1500 mg. >> >> Any tips or advice would be greatly appreciated. I really do want to >> stay on it..i was on Avandia but developed some serious edema. >> >> Thanks so much. >> >> maddy >> Dear Maddy: I found that an AlkaSelzer tablet taken once a day for a week or so removed the GI side effects for me. I only use it once a week now, but I still get some GI upset occasionally on 1500mg/day. AlkaSeltzer has bicarb in it and I think this is what works.. Glucophage can cause a mild acidosis in some people, and the bicarb reverses this. I have blood tests done every 8 wks and I have a mild elevation in the anion gap.. which suggests low bicarb. AlkaSeltzer Hearburn Refief has no aspirin in it for those who wish to avoid aspirin. Take care.
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