Re: Confused and Frustrated with Meds / Doctors
From: =?iso-8859-2?q?Zalányi Sámuel ?= (anonymous@obgyn.net)
Tue, 22 Jan 2002 20:04:08 +0100
Dear KEvin,
The #:RE is wrong on two accounts.
1. Spironolactone is PROHIBITED while TTC, bcause it can cause genital malformations in a male fetus
2. There is some debate about continuing metformin during pgy because there is a perceived risk of neural tube defects if you continue, but there is an increased risk of miscarriage if you discontinue. As the risk of NTD can be diminished by extra folic acid (800 mg/day) to prudent advice is TO CONTINUE METFORMIN.
For your info
Sam
> Hello there! We are having a bit of confusion and frustration with
> different doctors and what they prescribe.
>
> My wife was diagnosed with PCOS two years ago, and it was found that one
> of her ovaries was bad and was removed one year ago. Since then, she
> has been on a combined drug regiment of both spirnolactone and
> glucophage, which have successfully treated her symptoms to an
> acceptable level.
>
> We have recently begun to try to become pregnant, and the RE my wife has
> gone to started her on Clomid this month and told her that she could
> continue to take both the Spirnolactone and Glucophage along with the
> Clomid. She was told by a nurse to also take prenatal vitamins just in
> case she became pregnant.
>
> Last Friday night (Clomid day 4) my wife experienced severe digestive
> system distress (nausea, etc), chills, etc. We immediately called the
> on-call RE from our doctor's office. A different RE from the one my
> wife was seeing told my wife that we should NEVER be taking clomid with
> Spirnolactone together. This agrees with what our PCOS books tell us.
> In confusion, we contacted our RE yesterday who told us that it was the
> GLUCOPHAGE causing the problem, and to take the Spirnolactone again and
> drop the glucophage!
>
> As there is no supporting literature for this, we are now completely
> confused and frustrated, and wondering what to take, what not to take,
> which Dr. we can trust, etc. If anyone can shed any advice on this
> situation, we would be most appreciative!!
>
> Thanks,
> Kevin Jackey
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