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maybe Dr. Sam can help - On Glucophage and weight lossFrom: Muriel (anonymous@obgyn.net)Tue, 6 Nov 2001 08:30:30 -0800
Hi again, OK I have been trying to work through this Glucophage thing logically, not medically, and here are my conclusions. If Glucophage does NOT help you to lose weight, I conclude that you do not have an insulin problem. How can I say that? Follow my reasoning. Say you are obese, and you have trouble losing weight. You find out that you have PCOS and are prescribed Glucophage to regulate your insulin levels. The Glucophage may or may not make you sick, and you try several different dosages to attempt to find what is right for you. Your motivation? To become healthy with lesser risks of heart disease and diabetes, AND to lose weight. So you have been on glucophage for a couple of months, and you have not lost a single pound. You suffer from the side effects anyways because at least you will become "healthy" from this drug, while at the same time feeling lousy with diarrhea. If you claim to have Insulin resistance, and the glucophage is supposed to solve that problem, then logically you WILL lose weight because your body will adjust accordingly, better breaking down the sugars in your system. If you think you have insulin resistance, and you do NOT lose any weight with Glucophage, then how is it unreasonable to believe that your obesity problem lies NOT with insulin resistance, but something else (such as over eating, inactivity, non-PCOS-related hormone problems). Also, if you claim to be taking Glucophage in order to become healthier and to reduce the risk of diabetes and heart disease, yet you do not lose any weight, wouldn't the risk remain the same simply because of all the fat? Being overweight causes diabetes, being overweight causes heart disease. So how in the world can you give yourself better chances if weight loss does NOT occur? I may be 21, but I certainly care about my health and I am insulted by anyone who infers that I do not. I am losing weight on Glucophage (20 pounds within 2 months thus far), which leads me to believe that I do in fact have an insulin resistance problem, especially because I have not changed my diet (much). My opinion on the matter is that the most important thing you can do for yourself and for your health is to bring your weight down from dangerous levels to a more normal weight range (whatever is possible for people with PCOS). I think if you are not doing this, glucophage is little more than a placebo that gives you diarrhea. Muriel
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