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Re: Diets and excersise, or lack thereofFrom: Renee (anonymous@obgyn.net)Sun, 04 Nov 2001 08:59:51 -0800
While many women do lose weight from Glucophage, not all of us do. ( I have actually put on a few pounds lately, but they are starting to come off again.) I'm glad you have. The main reason we take it is not to lose weight. It is to control our insulin. With too much insulin floating around, two things happen. First, our receptor sites on our cells for the insulin get overwhelmed, and wear out. Think about your car with 150,000 miles on it, and there is no mechanic to fix anything. They stop working. The job of insulin in the body is to carry glucose through the cell walls. Glucose can't go through on it's own. So, if the receptor sites stop working, the glucose can't get through. So, the cells starve. This process is insulin resistance while some receptors are damaged, and type 2 diabetes when it's worse. All that insulin is floating around, and it has to do something. So, it does the other thing it can do: convert that extra blood sugar to fat. The pancreas pumps out more more insulin trying to get the sugar into the cells. It doesn't realize that there is already enough insulin out there and that the problem is the cells, not the insulin. It only gets a message saying "we need more glucose in the cells." Eventually, the pancreas wears out too, and stops producing insulin. This is when people with type 2 diabetes need to take insulin as well as an insulin sensitizer. Therefore, the main reason we take glucophage is for the long term. We want to control the insulin resistance and prevent diabetes from developing, or at least delay it. So, there definitely are reasons why some of us won't lose weight. The glucophage may limit or prevent further fat deposition, but there is no guarantee. I hope this helps to explain the metabolic reason for taking met. Renee
Muriel and John Montgomery wrote:
> -- Renee Cordrey, MSPT, MPH, CWS---
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