PCOS-MEDICATION Messages for October, 2001: Re: hair loss

Re: hair loss

From: Aaron (anonymous@obgyn.net)
Thu, 11 Oct 2001 03:32:40 -0500 (CDT)

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Lynn, Hi, I can relate. I am 25 and I'm wondering if I am losing my hair. I remember that my hair line has been high all of my life, and due to a near fatal car accident, about six yrs ago, I suffered amnesia, and can't remember, very clearly, how high my hair line used to be. I've been researching hair loss prevention for about four hours now, and I'll share some good stuff that I've gathered:

"Androgenic alopecia At the hair follicle, testosterone is converted by an enzyme called 5 alpha reductase into another form of testosterone called dihydrotestosterone or DHT, for short. DHT is the androgen hormone that triggers hair loss in androgenetic alopecia. When hair follicles that are genetically programmed to be receptive to DHT receive the DHT message over a long enough period of time, the follicle begins to produce less hair. Individuals with a deficiency in 5 alpha reductase do not develop androgenetic alopecia. This is because the body is unable to convert testosterone into dihydrotestosterone. When androgenetic alopecia occurs large active hair follicles in specific areas begin to change to smaller less active ones that shrink slightly with each new growth cycle. The enzyme 5 alpha reductase is thought to be the major cause of this. Under the action of the enzyme the male hormone testosterone become dihydrotestosterone. This causes the hair shafts to narrow producing progressively finer hairs with each new growth cycle until eventually the hairs become transparent and stop emerging. If an individual has androgenetic alopecia the overall levels of testosterone may be normal however the activity of 5 alpha reductase is greater than normal which results in increased amounts of dihydrotestosterone in the in the hair follicle.

Treatments for Androgenetic alopecia Inhouse Pharmacy are able to supply the following products which are commonly used in the treatment of Androgenetic alopecia; Topical Minoxidil which is supplied as either: Regaine or Headway Propecia (finasteride) Propecia is a relatively new drug produce by Merck. It is a tablet which is taken once a day and at this present time it is only approved for use in men. Propecia is not to be used by woman and children. Propecia is a 4 aza steroid compound that is a specific inhibitor of type 2 5 alpha reductase which is the enzyme that metabolises the androgen testosterone into dihydrotestosterone (DHT). Saw Palmetto extract Studies have shown that saw palmetto es is an effective anti-androgen. It acts in a similar way that propecia does. Firstly it lowers levels of DHT in the body by blocking 5 alpha-reductase. Secondly Saw Palmetto block receptor sites on cell membranes required for cells to absorb DHT. Although no studies have been carried out on saw palmetto and its relation to hair growth. Studies have been performed on the use of Saw palmetto in the treatment of benign prostatic disease which similar to Androgenetic alopecia also depends on the production of dihydrotestosterone. All of the studies that have been performed to date show that Saw palmetto is an effective antiandrogen and has shown conclusively to be effective in the treatment of benign prostratic disease. One may assume from this that since Saw palmetto is an effective antiandrogen and is used in the treatment of prostatic disease then it may also be effective in the treatment of Androgenetic alopecia. "

Stress as well as dihydrotes. causes hair loss. Cortisol is produced from stress. The suppression of cortisol, through the release of arginine vasotocin, increases levels of melatonin and can decrease hair loss; or so I've gathered(http://www.nutrimart.com/melaton.htm).

God bless, and write back if you have any consolation/advice/knowledge, Aaron

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