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Glucophage/Metformin non-PCOS pregnancyFrom: anonymous (anonymous@obgyn.net)Mon, 3 Sep 2001 00:47:08 -0500 (CDT)
My wife and I have recently become pregnant. On consulting with her OB, it was dicovered that while not diabetic, she is insulin resistant (I'll cal it IR). Our OB recommended 1500mg of glucophage/metformin to deal with her IR, and it sounds like he wants her to take it for the full term of the pregnancy and beyond, until she can stabilize her IR through exercise and diet (which we are assuming she can). We have found snippets of both the Glueck and Hellmuth studies, and are bit confused by what the healthiest decisions are for both my wife and our baby. We feel relatively ok with the glucophage through the first trimester (but still have questions for the OB), as it should help her with the insulin levels, and hopefully give us less of a chance of miscarriage. But what about beyond that? The Glueck study is great to hear (and the OB seems to be a supporter of the philosophy - his office has been using it for PCOS patients for a year now). But for one thing, my wife is not a PCOS patient, and the Hellmuth study is a bit frightening with the perinatal deaths that occured. Does anyone have any more information on the use of glucophage during pregnancy on someone who is only IR, and NOT a PCOS patient? If possible, we would also like to see both of the studies in full. (One of my big questions on the Hellmuth study is, what exactly was the cause of the perinatal deaths in the subset of glucophage babies - was it the same across the board, and can it be traced back to glucophage?). Information on any other studies that may have been done would also be great. Any help is greatly appreciated! Thank you!
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